Abstract

Ultra-low-field (ULF) nuclear magnetic resonance (NMR) is a promising spectroscopy method allowing for, e.g., the simultaneous detection of multiple nuclei. To overcome the low signal-to-noise ratio that usually hampers a wider application, we present here an alternative approach to ULF NMR, which makes use of the hyperpolarizing technique signal amplification by reversible exchange (SABRE). In contrast to standard parahydrogen hyperpolarization, SABRE can continuously hyperpolarize 1 H as well as other MR-active nuclei. For simultaneous measurements of 1 H and 19 F under SABRE conditions a superconducting quantum interference device (SQUID)-based NMR detection unit was adapted. We successfully hyperpolarized fluorinated pyridine derivatives with an up to 2000-fold signal enhancement in 19 F. The detected signals may be explained by two alternative reaction mechanisms. SABRE combined with simultaneous SQUID-based broadband multinuclear detection may enable the quantitative analysis of multinuclear processes.

Details

Title
SQUID-based detection of ultra-low-field multinuclear NMR of substances hyperpolarized using signal amplification by reversible exchange
Author
Buckenmaier, K 1 ; Rudolph, M 2 ; Back, C 3 ; Misztal, T 4 ; Bommerich, U 5 ; Fehling, P 1 ; Koelle, D 3 ; Kleiner, R 3 ; Mayer, H A 4   VIAFID ORCID Logo  ; Scheffler, K 1 ; Bernarding, J 5   VIAFID ORCID Logo  ; Plaumann, M 5   VIAFID ORCID Logo 

1  High-Field Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Spemannstr. 41, Tübingen, Germany 
2  High-Field Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Spemannstr. 41, Tübingen, Germany; Physikalisches Institut and Center for Quantum Science (CQ) in LISA+, University of Tübingen, Tübingen, Germany 
3  Physikalisches Institut and Center for Quantum Science (CQ) in LISA+, University of Tübingen, Tübingen, Germany 
4  Institute of Inorganic Chemistry, University of Tübingen, Tübingen, Germany 
5  Department for Biometrics and Medical Informatics, Otto-von-Guericke University, Magdeburg, Germany 
Pages
1-9
Publication year
2017
Publication date
Oct 2017
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41598-017-13757-7
ProQuest document ID
2121471771
Copyright
© 2017. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.