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Abstract
Diet and exercise are conventional methods for controlling body weight and are linked to alterations in gut microbiota. However, the associations of diet, exercise, and gut microbiota in the control of obesity remain largely unknown. In the present study, using 16S rRNA amplicon sequencing and fecal microbiota transplantation (FMT), normal fat diet (NFD), exercise and their combination resulted in improved metabolic profiles in comparison to sedentary lifestyle with high fat diet (HFD). Moreover, diet exerted more influence than exercise in shaping the gut microbiota. HFD-fed mice receiving FMT from NFD-exercised donors not only showed remarkably reduced food efficacy, but also mitigated metabolic profiles (p < 0.05). The transmissible beneficial effects of FMT were associated with bacterial genera Helicobacter, Odoribacter and AF12 and overrepresentation of oxidative phosphorylation and glycolysis genes. Our findings demonstrate that the beneficial effects of diet and exercise are transmissible via FMT, suggesting a potential therapeutic treatment for obesity.
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Details
1 Division of Gastroenterology, Taichung Veterans General Hospital, Taichung, Taiwan
2 Germark Biotechnology Co., Ltd., Taichung, Taiwan
3 Institute of Digestive Disease, the Chinese University of, Shatin, Hong Kong
4 Faculty of Medicine and Graduate Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Dermatology, Taichung Veterans General Hospital, Taichung, Taiwan
5 Stem Cell Center, Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan
6 Department of Internal Medicine, E-Da Hospital/I-Shou University, Kaohsiung, Taiwan; Graduate Institute of Clinical Medicine, China Medical University, Taichung, Taiwan
7 School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan; Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan
8 Microbiome Research Centre, St George and Sutherland Clinical School, University of New South Wales, Sydney, Australia
9 Division of Gastroenterology, Taichung Veterans General Hospital, Taichung, Taiwan; Faculty of Medicine and Graduate Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan; Graduate Institute of Clinical Medicine, China Medical University, Taichung, Taiwan; Division of Translational Research, Taipei Veterans General Hospital, Taipei, Taiwan; National Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan; Department of Public Health, China Medical University, Taichung, Taiwan; Department of Life Sciences and Rong Hsing Research Center for Translational Medicine, National Chung-Hsing University, Taichung, Taiwan