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Copyright © 2014. This work is published under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

肺癌是世界范围内最常见的恶性肿瘤之一,其中约80%为非小细胞肺癌,其发病机制至今尚未完全阐明。最近研究证实基质金属蛋白酶(matrix metalloproteinases, MMPs)的调节异常和过度表达与多种疾病相关,其中有研究显示基质金属蛋白酶家族中的基质金属蛋白酶12(MMP-12)参与了非小细胞肺癌的浸润和转移。在非小细胞肺癌组织中MMP-12的表达明显高于癌旁组织,且MMP-12对非小细胞肺癌患者的预后评估亦有重要意义。因此,本文将围绕MMP-12在非小细胞肺癌中的研究进行简要的总结。

Lung cancer is one of the most common malignant tumors in the world wide. Non-small cell lung cancer (NSCLC) accounts for approximately 80% of lung cancers, its pathogenesis have not been elucidated. Recently, researches have shown that dysregulation and excessive activity of the matrix metalloproteinases (MMPs) has been associated with many pathologies. Some results suggest that the matrix metalloproteinases 12 (MMP-12) participates in the invasion and metastasis of NSCLC. The expression of MMP-12 in non-small cell lung cancer is significantly higher than in adjacent tissues. And studies have shown that the MMP-12 has important prognostic significance in NSCLC. Therefore this article will briefly summarize the research progresses of MMP-12 in NSCLC.

Details

Title
Research Progress of Matrix Metalloproteinase 12 in Non-small Cell Lung Cancer
Author
Yuan, WEN; CAI, Li
Pages
30-33
Section
Minireview
Publication year
2014
Publication date
2014
Publisher
Chinese Anti-Cancer Association Chinese Antituberculosis Association
ISSN
10093419
e-ISSN
19996187
Source type
Scholarly Journal
Language of publication
Chinese
ProQuest document ID
2126967874
Copyright
Copyright © 2014. This work is published under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.