Abstract

In Africa, Old World Primates are involved in the maintenance of sylvatic circulation of ZIKV. However, in Brazil, the hosts for the sylvatic cycle remain unknown. We hypothesized that free-living NHPs might play a role in urban/periurban ZIKV dynamics, thus we undertook an NHP ZIKV investigation in two cities in Brazil. We identified ZIKV-positive NHPs and sequences obtained were phylogenetically related to the American lineage of ZIKV. Additionally, we inoculated four C. penicillata with ZIKV and our results demonstrated that marmosets had a sustained viremia. The natural and experimental infection of NHPs with ZIKV, support the hypothesis that NHPs may be a vertebrate host in the maintainance of ZIKV transmission/circulation in urban tropical settings. Further studies are needed to understand the role they may play in maintaining the urban cycle of the ZIKV and how they may be a conduit in establishing an enzootic transmission cycle in tropical Latin America.

Details

Title
Evidence of natural Zika virus infection in neotropical non-human primates in Brazil
Author
Terzian, Ana Carolina B 1 ; Zini, Nathalia 1 ; Sacchetto, Lívia 2 ; Rebeca Froes Rocha 3 ; Maisa Carla Pereira Parra 1 ; Juliana Lemos Del Sarto 3 ; Fialho Dias, Ana Carolina 3 ; Coutinho, Felipe 3 ; Rayra, Jéssica 3 ; Rafael Alves da Silva 1 ; Vivian Vasconcelos Costa 3 ; Natália Coelho Couto De Azevedo Fernandes 4 ; Réssio, Rodrigo 4 ; Díaz-Delgado, Josué 4 ; Guerra, Juliana 4 ; Cunha, Mariana S 4 ; Catão-Dias, José Luiz 5   VIAFID ORCID Logo  ; Bittar, Cintia 6   VIAFID ORCID Logo  ; Andréia Francesli Negri Reis 7 ; Izalco Nuremberg Penha dos Santos 7 ; Andréia Cristina Marascalchi Ferreira 7 ; Lilian Elisa Arão Antônio Cruz 7 ; Rahal, Paula 6 ; Ullmann, Leila 8 ; Malossi, Camila 8 ; João Pessoa de Araújo Jr 8 ; Widen, Steven 9 ; de Rezende, Izabela Maurício 2 ; Mello, Érica 10 ; Pacca, Carolina Colombelli 11 ; Kroon, Erna Geessien 2 ; Trindade, Giliane 2 ; Drumond, Betânia 2 ; Chiaravalloti-Neto, Francisco 12   VIAFID ORCID Logo  ; Vasilakis, Nikos 13 ; Teixeira, Mauro M 3 ; Maurício Lacerda Nogueira 1   VIAFID ORCID Logo 

1  São José do Rio Preto School of Medicine (FAMERP), Avenida Brigadeiro Faria Lima, 5416, CEP: 15090-000, São José do Rio Preto, SP, Brazil 
2  Laboratório de Vírus - Universidade Federal de Minas Gerais (UFMG), Avenida Antônio Carlos, 6627, CEP: 31270-901, Pampulha, Belo Horizonte, MG, Brazil 
3  Center for Drug Research and Development, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Avenida Antônio Carlos, 6627, CEP: 31270-901, Pampulha, Belo Horizonte, MG, Brazil 
4  Instituto Adolfo Lutz (IAL), Avenida Dr. Arnaldo, 351 − 7 Andar, Sala 706, CEP: 01246-000, Pacaembú, São Paulo, SP, Brazil 
5  Laboratory of Wildlife Comparative Pathology, Department of Pathology, School of Veterinary Medicine and Animal Sciences, University of São Paulo (LAPOCM-FMVZ-USP), Avenida Orlando Marques de Paiva, 87, CEP: 05508-270, São Paulo, SP, Brazil 
6  Department of Biology, Institute of Biosciences, Letters, and Exact Sciences – São Paulo State University, São José do Rio Preto – (IBILCE/UNESP), São José do Rio Preto, SP, Brazil 
7  Epidemiological Surveillance Departament of São José do Rio Preto, Avenida Romeu Strazzi, 199, CEP: 15084-010, Vila Sinibaldi, São José do Rio Preto, SP, Brazil 
8  São Paulo State University (Unesp), Institute for Biotechnology, Alameda das Tecomarias, s/n, CEP: 18607-440, Chácara Capão Bonito, Botucatu, SP, Brazil 
9  Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, USA 
10  Centro de Controle de Zoonoses, Belo Horizonte Council, Rua Édna Quintel, 173, CEP: 31270-705, São Bernardo, Belo Horizonte, MG, Brazil 
11  Faceres Medical School, Avenida Anísio Haddad, 6751, CEP: 15090-305, Jardim Francisco Fernandes, São José do Rio Preto, SP, Brazil 
12  Department of Epidemiology, School of Public Health of the University of São Paulo, Avenida Dr. Arnaldo, 715, CEP: 01246-904, São Paulo, SP, Brazil 
13  Department of Pathology and Center of Biodefense and Emerging Infectious Diseases, Center for Tropical Diseases, Institute for Human Infections and Immunity, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, USA 
Pages
1-15
Publication year
2018
Publication date
Oct 2018
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41598-018-34423-6
ProQuest document ID
2127189694
Copyright
© 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.