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© 2018. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Periodontal disease is an infection that, in pregnant women, can act as a risk factor for preterm delivery by increasing local and systemic inflammatory responses. Objective. To analyze the presence of periodontal disease, proinflammatory cytokines, and prostaglandin E2 (PGE2) in pregnant patients at high risk for preterm delivery. Materials and Methods. Pilot study for a case-control study We included 46 pregnant patients (23 patients at risk of preterm delivery as cases and 23 patients without risk of preterm delivery as controls). We excluded patients who received periodontal treatment, antibiotics, or antimicrobials over the last 3 months as well as those with infections or diseases such as diabetes or hypercholesterolemia. The patients underwent a periodontal assessment, and their levels of cytokines (interleukin- [IL-] 2, IL-6, IL-10, and tumor necrosis factor- [TNF-] α) and prostaglandin E2 (PGE2) were quantified. Results. Patients with periodontal disease showed higher levels of cytokines (IL-2, IL-6, IL-10, and TNFα) and PGE2. Patients at high risk for preterm birth showed higher IL levels compared with patients at low risk for preterm delivery. PGE2 increased with the severity of periodontal disease. PGE2 was higher in patients at low risk for preterm delivery, although this difference was not significant. Conclusion. Periodontal disease can increase the systemic inflammatory response as well as the levels of PGE2 and inflammatory cytokines in pregnant patients.

Details

Title
Periodontal Disease, Inflammatory Cytokines, and PGE^sub 2^ in Pregnant Patients at Risk of Preterm Delivery: A Pilot Study
Author
Uriza, Catalina Latorre 1 ; Velosa-Porras, Juliana 2 ; Roa, Nelly S 2 ; Lara, Stephani Margarita Quiñones 2 ; Silva, Jaime 3 ; Ruiz, Alvaro J; Arregoces, Francina Maria Escobar

 Centro de Investigaciones Odontológicas (CIO), Professor Graduate Program in Periodontics, Faculty of Dentistry, Pontificia Universidad Javeriana, Colombia 
 Centro de Investigaciones Odontológicas (CIO), Faculty of Dentistry, Pontificia Universidad Javeriana, Bogota, Colombia 
 Hospital Universitario San Ignacio, Colombia 
Pages
1-7
Section
Research Article
Publication year
2018
Publication date
2018
Publisher
John Wiley & Sons, Inc.
ISSN
10647449
e-ISSN
10980997
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2127358860
Copyright
© 2018. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.