Abstract

Background

In 2017 the Nigerian Ministry of Health notified the World Health Organization (WHO) of an outbreak of hepatitis E located in the north-east region of the country with 146 cases with 2 deaths. The analysis of the hepatitis E virus (HEV) genotypes responsible for the outbreak revealed the predominance of HEV genotypes 1 (HEV-1) and 2 (HEV-2). Molecular data of HEV-2 genomes are limited; therefore we characterized a HEV-2 strain of the outbreak in more detail.

Finding

The full-length genome sequence of an HEV-2 strain (NG/17–0500) from the outbreak was amplified using newly designed consensus primers. Comparison with other HEV complete genome sequences, including the only HEV-2 strain (Mex-14) with available complete genome sequences and the availability of data of partial HEV-2 sequences from Sub-Saharan Africa, suggests that NG/17–0500 belongs to HEV subtype 2b (HEV-2b).

Conclusions

We identified a novel HEV-2b strain from Sub-Saharan Africa, which is the second complete HEV-2 sequence to date, whose natural history and epidemiology merit further investigation.

Details

Title
A new hepatitis E virus genotype 2 strain identified from an outbreak in Nigeria, 2017
Author
Wang, Bo; Akanbi, Olusola Anuoluwapo; Harms, Dominik; Adesina, Olufisayo; Osundare, Folakemi Abiodun; Naidoo, Dhamari; Deveaux, Isabel; Ogundiran, Opeayo; Ugochukwu, Uzoma; Mba, Nwando; Ihekweazu, Chikwe; C-Thomas, Bock
Publication year
2018
Publication date
2018
Publisher
BioMed Central
ISSN
1743-422X
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/s12985-018-1082-8
ProQuest document ID
2135486816
Copyright
Copyright © 2018. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.