Abstract

The apoE4 isoform is associated with increased cholesterol, cardiovascular risk, and Alzheimer’s Disease risk, however, its distribution is not well-understood among US Latinos. Latinos living in the US are highly Amerindian, European and African admixed, which varies by region and country of origin. However, Latino genetic diversity is understudied and consequently poorly understood, which has significant implications for understanding disease risk in nearly one-fifth of the US population. In this report we describe apoE distributions in a large and representative sample of diverse, genetically determined US Latinos.

Details

Title
Apolipoprotein E genotypes among diverse middle-aged and older Latinos: Study of Latinos-Investigation of Neurocognitive Aging results (HCHS/SOL)
Author
González, Hector M 1 ; Tarraf, Wassim 2 ; Xueqiu Jian 3 ; Vásquez, Priscilla M 1 ; Kaplan, Robert 4 ; Thyagarajan, Bharat 5   VIAFID ORCID Logo  ; Daviglus, Martha 6 ; Lamar, Melissa 7 ; Gallo, Linda C 8 ; Zeng, Donglin 9 ; Fornage, Myriam 10 

 Department of Neurosciences and Shiley-Marcos Alzheimer’s Disease Research Center, University of California, San Diego, La Jolla, CA, USA 
 Institute of Gerontology & Department of Healthcare Sciences, Wayne State University, Detroit, Michigan, USA 
 Institute of Molecular Medicine, McGovern Medical School University of Texas Health Science Center, Houston, TX, USA 
 Albert Einstein, College of Medicine, New York, USA 
 Department of Laboratory Medicine and Pathology, University of Minnesota Medical Center Fairview, Minneapolis, Minnesota, USA 
 Institute for Minority Health Research, University of Illinois at Chicago, College of Medicine, Chicago, Illinois, USA 
 Rush University, Chicago, IL, USA 
 Institute for Behavioral and Community Health, Graduate School of Public Health, San Diego State University, San Diego, California, USA 
 Department of Biostatistics, Collaborative Studies Coordinating Center, University of North Carolina, Chapel Hill, North Carolina, USA 
10  Institute of Molecular Medicine, McGovern Medical School University of Texas Health Science Center, Houston, TX, USA; Human Genetics Center, School of Public Health, University of Texas Health Science Center, Houston, TX, USA 
Pages
1-6
Publication year
2018
Publication date
Dec 2018
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2155896376
Copyright
© 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.