Details
Title
Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis
Author
Martínez-Fábregas, Jonathan 1 ; Prescott, Alan 1 ; Sander van Kasteren 2
; Pedrioli, Deena Leslie 3 ; McLean, Irwin 4
; Moles, Anna 5 ; Reinheckel, Thomas 6 ; Poli, Valeria 7
; Watts, Colin 1
1 Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee, UK
2 Division of Bio-Organic Chemistry, Leiden Institute of Chemistry, Leiden, Netherlands
3 Division of Molecular Medicine, School of Life Sciences, University of Dundee, Dundee, UK; Department of Molecular Mechanisms of Disease, University of Zurich, Winterthurestrasse190, Switzerland
4 Division of Molecular Medicine, School of Life Sciences, University of Dundee, Dundee, UK
5 Fibrosis Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK; Institute of Biomedical Research of Barcelona, Spanish Research Council, Barcelona, Spain
6 Institute of Molecular Medicine and Cell Research, Medical Faculty, Albert-Ludwigs-University, Freiburg, Germany
7 Department of Genetics, Biology and Biochemistry, University of Turin, Turin, Italy
; Pedrioli, Deena Leslie 3 ; McLean, Irwin 4
; Moles, Anna 5 ; Reinheckel, Thomas 6 ; Poli, Valeria 7
; Watts, Colin 1
1 Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee, UK
2 Division of Bio-Organic Chemistry, Leiden Institute of Chemistry, Leiden, Netherlands
3 Division of Molecular Medicine, School of Life Sciences, University of Dundee, Dundee, UK; Department of Molecular Mechanisms of Disease, University of Zurich, Winterthurestrasse190, Switzerland
4 Division of Molecular Medicine, School of Life Sciences, University of Dundee, Dundee, UK
5 Fibrosis Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK; Institute of Biomedical Research of Barcelona, Spanish Research Council, Barcelona, Spain
6 Institute of Molecular Medicine and Cell Research, Medical Faculty, Albert-Ludwigs-University, Freiburg, Germany
7 Department of Genetics, Biology and Biochemistry, University of Turin, Turin, Italy
Pages
1-16
Publication year
2018
Publication date
Dec 2018
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2157865900
Copyright
© 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.