Abstract

Mutations in nucleotide-binding oligomerization domain protein 12 (NLRP12) are known to effect inflammatory processes. Here the authors show that NLRP12-mediated proteasomal degradation of NOD2 in monocytes promotes bacterial tolerance and colonisation in a model of enteric infection.

Details

Title
Proteasomal degradation of NOD2 by NLRP12 in monocytes promotes bacterial tolerance and colonization by enteropathogens
Author
Normand, Sylvain 1 ; Waldschmitt, Nadine 2 ; Neerincx, Andreas 3 ; Martinez-Torres, Ruben Julio 4 ; Chauvin, Camille 1 ; Couturier-Maillard, Aurélie 1 ; Boulard, Olivier 1 ; Cobret, Laetitia 5 ; Awad, Fawaz 5 ; Huot, Ludovic 1 ; Ribeiro-Ribeiro, Andre 4 ; Lautz, Katja 6 ; Ruez, Richard 1 ; Delacre, Myriam 1 ; Bondu, Clovis 1 ; Guilliams, Martin 7   VIAFID ORCID Logo  ; Scott, Charlotte 7 ; Segal, Anthony 4 ; Amselem, Serge 5 ; Hot, David 1   VIAFID ORCID Logo  ; Karabina, Sonia 5 ; Bohn, Erwin 8 ; Ryffel, Bernhard 9 ; Poulin, Lionel F 1 ; Kufer, Thomas A 10   VIAFID ORCID Logo  ; Chamaillard, Mathias 1 

 University of Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Centre d′Infection et d′Immunité de Lille, Lille, France 
 University of Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Centre d′Infection et d′Immunité de Lille, Lille, France; Technische Universität München, Chair of Nutrition and Immunology, Freising-Weihenstephan, Germany 
 Department of Pathology, University of Cambridge, Cambridge, UK 
 Division of Medicine, University College London, London, UK 
 Sorbonne Universités, UPMC Univ Paris 06, UMR_S 933, Paris, France; Inserm, UMR_S 933, Paris, France 
 Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany 
 Laboratory of Immunoregulation, VIB Inflammation Research Center, Ghent, Belgium; Department of Internal Medicine, Ghent University, Ghent, Belgium 
 Interfakultaeres Institut für Mikrobiologie und Infektionsmedizin, Eberhard Karl Universitat Tuebingen, Tuebingen, Germany 
 CNRS, Orléans University, INEM, UMR 7355, Orléans, France 
10  Department of Immunology, Institute of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany 
Pages
1-11
Publication year
2018
Publication date
Dec 2018
Publisher
Nature Publishing Group
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2157866103
Copyright
© 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.