Abstract

Noisy gene expression leading to phenotypic variability can help organisms to survive in changing environments. Here, Patange et al. show that noisy expression of a stress response regulator, RpoS, allows E. coli cells to modulate their growth rates to survive future adverse environments.

Details

Title
Escherichia coli can survive stress by noisy growth modulation
Author
Patange, Om 1   VIAFID ORCID Logo  ; Schwall, Christian 1 ; Jones, Matt 2   VIAFID ORCID Logo  ; Villava, Casandra 2 ; Griffith, Douglas A 2 ; Phillips, Andrew 3   VIAFID ORCID Logo  ; Locke, James C W 4 

1  Sainsbury Laboratory, University of Cambridge, Cambridge, UK; Department of Biochemistry, University of Cambridge, Cambridge, UK 
2  Sainsbury Laboratory, University of Cambridge, Cambridge, UK 
3  Microsoft Research, Cambridge, UK 
4  Sainsbury Laboratory, University of Cambridge, Cambridge, UK; Department of Biochemistry, University of Cambridge, Cambridge, UK; Microsoft Research, Cambridge, UK 
Pages
1-11
Publication year
2018
Publication date
Dec 2018
Publisher
Nature Publishing Group
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41467-018-07702-z
ProQuest document ID
2157866119
Copyright
© 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.