Abstract

Long non-coding RNAs transcribed at DNA damaged sites can play part in DNA damage response. Here the authors reveal that damaged induced lncRNAs can form DNA:RNA hybrids at resected DNA-ends. These hybrids are involved in recruiting HR-mediated repair machinery which, in turn, controls their level at DSBs.

Details

Title
BRCA2 controls DNA:RNA hybrid level at DSBs by mediating RNase H2 recruitment
Author
Giuseppina D’Alessandro 1 ; Donna Rose Whelan 2   VIAFID ORCID Logo  ; Howard, Sean Michael 3 ; Vitelli, Valerio 1 ; Renaudin, Xavier 4 ; Adamowicz, Marek 5 ; Iannelli, Fabio 1 ; Corey Winston Jones-Weinert 1 ; Lee, MiYoung 4 ; Matti, Valentina 1 ; Lee, Wei Ting C 2 ; Morten, Michael John 2 ; Venkitaraman, Ashok Raraakrishnan 4 ; Cejka, Petr 6 ; Rothenberg, Eli 2 ; Fabrizio d’Adda di Fagagna 7   VIAFID ORCID Logo 

 IFOM, the FIRC Institute of Molecular Oncology, Milan, Italy 
 Department of Biochemistry and Molecular Pharmacology, NYU School of Medicine, New York, NY, USA 
 Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland 
 Medical Research Council Cancer Unit, University of Cambridge, Cambridge, UK 
 IFOM, the FIRC Institute of Molecular Oncology, Milan, Italy; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, Brighton, UK 
 Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland; Department of Biology, Institute of Biochemistry, Swiss Federal Institute of Technology, Zurich, Switzerland 
 IFOM, the FIRC Institute of Molecular Oncology, Milan, Italy; Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche (IGM-CNR), Pavia, Italy 
Pages
1-17
Publication year
2018
Publication date
Dec 2018
Publisher
Nature Publishing Group
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2158234793
Copyright
© 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.