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Abstract
Long non-coding RNAs transcribed at DNA damaged sites can play part in DNA damage response. Here the authors reveal that damaged induced lncRNAs can form DNA:RNA hybrids at resected DNA-ends. These hybrids are involved in recruiting HR-mediated repair machinery which, in turn, controls their level at DSBs.
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1 IFOM, the FIRC Institute of Molecular Oncology, Milan, Italy
2 Department of Biochemistry and Molecular Pharmacology, NYU School of Medicine, New York, NY, USA
3 Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland
4 Medical Research Council Cancer Unit, University of Cambridge, Cambridge, UK
5 IFOM, the FIRC Institute of Molecular Oncology, Milan, Italy; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, Brighton, UK
6 Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland; Department of Biology, Institute of Biochemistry, Swiss Federal Institute of Technology, Zurich, Switzerland
7 IFOM, the FIRC Institute of Molecular Oncology, Milan, Italy; Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche (IGM-CNR), Pavia, Italy