Abstract

Acute kidney injury (AKI) is a common reactive oxygen species (ROS)-related renal disease that causes numerous deaths annually, yet only supportive treatment is currently available in the clinics. Development of antioxidants with high accumulation rates in kidneys is highly desired to help prevent AKI. Here we report molybdenum-based polyoxometalate (POM) nanoclusters with preferential renal uptake as novel nano-antioxidants for kidney protection. These POM nanoclusters, with a readily variable valence state of molybdenum ions, possess the capability to scavenge detrimental ROS. Our results demonstrate that POM nanoclusters can efficiently alleviate clinical symptoms in mice subjected to AKI, as verified by dynamic PET imaging with 68Ga-EDTA, serum tests, kidney tissue staining, and biomarkers detection in the kidneys. The protective effect of POM nanoclusters against AKI in living animals suggests exploring their use for the treatment of AKI patients, as well as patients with other ROS-related diseases.

Details

Title
Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice
Author
Ni, Dalong 1 ; Jiang, Dawei 2   VIAFID ORCID Logo  ; Kutyreff, Christopher J 1 ; Lai, Jianhao 3 ; Yan, Yongjun 1 ; Barnhart, Todd E 1   VIAFID ORCID Logo  ; Yu, Bo 1 ; Hyung-Jun Im 1 ; Kang, Lei 1 ; Cho, Steve Y 1 ; Liu, Zhaofei 4   VIAFID ORCID Logo  ; Huang, Peng 5   VIAFID ORCID Logo  ; Engle, Jonathan W 1 ; Cai, Weibo 6   VIAFID ORCID Logo 

1  Departments of Radiology and Medical Physics, University of Wisconsin, Madison, WI, USA 
2  Departments of Radiology and Medical Physics, University of Wisconsin, Madison, WI, USA; Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University, Shenzhen, China 
3  Departments of Radiology and Medical Physics, University of Wisconsin, Madison, WI, USA; Medical Isotopes Research Center and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China 
4  Medical Isotopes Research Center and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China 
5  Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University, Shenzhen, China 
6  Departments of Radiology and Medical Physics, University of Wisconsin, Madison, WI, USA; University of Wisconsin Carbone Cancer Center, Madison, WI, USA 
Pages
1-11
Publication year
2018
Publication date
Dec 2018
Publisher
Nature Publishing Group
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41467-018-07890-8
ProQuest document ID
2159700738
Copyright
© 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.