Abstract

MicroRNA exhibits differential expression levels in cancer and can affect cellular transformation, carcinogenesis and metastasis. Although fluorescence techniques using dye molecule labels have been studied, label-free molecular-level quantification of miRNA is extremely challenging. We developed a surface plasmon resonance sensor based on two-dimensional nanomaterial of antimonene for the specific label-free detection of clinically relevant biomarkers such as miRNA-21 and miRNA-155. First-principles energetic calculations reveal that antimonene has substantially stronger interaction with ssDNA than the graphene that has been previously used in DNA molecule sensing, due to thanking for more delocalized 5s/5p orbitals in antimonene. The detection limit can reach 10 aM, which is 2.3–10,000 times higher than those of existing miRNA sensors. The combination of not-attempted-before exotic sensing material and SPR architecture represents an approach to unlocking the ultrasensitive detection of miRNA and DNA and provides a promising avenue for the early diagnosis, staging, and monitoring of cancer.

Details

Title
Ultrasensitive detection of miRNA with an antimonene-based surface plasmon resonance sensor
Author
Xue, Tianyu 1 ; Liang, Weiyuan 1 ; Li, Yawen 2 ; Sun, Yuanhui 2 ; Yuanjiang Xiang 1 ; Zhang, Yupeng 1 ; Dai, Zhigao 3 ; Yanhong Duo 1 ; Wu, Leiming 1 ; Qi, Kun 1 ; Bannur Nanjunda Shivananju 1 ; Zhang, Lijun 2   VIAFID ORCID Logo  ; Cui, Xiaoqiang 2 ; Zhang, Han 1   VIAFID ORCID Logo  ; Bao, Qiaoliang 4   VIAFID ORCID Logo 

1  Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Electronic Science and Technology and College of Optoelectronics Engineering, Shenzhen University, Shenzhen, People’s Republic of China 
2  School of Materials Science and Engineering and Key Laboratory of Automobile Materials of MOE, Jilin University, Changchun, Jilin, People’s Republic of China 
3  Department of Materials Science and Engineering, ARC Centre of Excellence in Future Low-Energy Electronics Technologies (FLEET), Monash University, Clayton, VIC, Australia; School of Printing and Packaging and School of Physics and Technology, Wuhan University, Wuhan, Hubei Province, People’s Republic of China 
4  Department of Materials Science and Engineering, ARC Centre of Excellence in Future Low-Energy Electronics Technologies (FLEET), Monash University, Clayton, VIC, Australia 
Pages
1-9
Publication year
2019
Publication date
Jan 2019
Publisher
Nature Publishing Group
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41467-018-07947-8
ProQuest document ID
2163007673
Copyright
© 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.