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Copyright © 2013 Jackson Roberto Guedes da Silva Almeida et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0/

Abstract

Borneol, a bicyclic monoterpene, has been evaluated for antinociceptive and anti-inflammatory activities. Antinociceptive and anti-inflammatory activities were studied by measuring nociception by acetic acid, formalin, hot plate, and grip strength tests, while inflammation was prompted by carrageenan-induced peritonitis. The rotarod test was used to evaluate motor coordination. Borneol produced a significant ( P < 0.01 ) reduction of the nociceptive behavior at the early and late phases of paw licking and reduced the writhing reflex in mice (formalin and writhing tests, resp.). When the hot plate test was conducted, borneol (in higher dose) produced an inhibition ( P < 0.05 ) of the nociceptive behavior. Such results were unlikely to be provoked by motor abnormality. Additionally, borneol-treated mice reduced the carrageenan-induced leukocytes migration to the peritoneal cavity. Together, our results suggest that borneol possess significant central and peripheral antinociceptive activity; it has also anti-inflammatory activity. In addition, borneol did not impair motor coordination.

Details

Title
Borneol, a Bicyclic Monoterpene Alcohol, Reduces Nociceptive Behavior and Inflammatory Response in Mice
Author
Jackson Roberto Guedes da Silva Almeida 1 ; Grasielly Rocha Souza 1 ; Juliane Cabral Silva 1 ; Sarah Raquel Gomes de Lima Saraiva 1 ; Raimundo Gonçalves de Oliveira Júnior 1 ; Jullyana de Souza Siqueira Quintans 2 ; Rosana de Souza Siqueira Barreto 2 ; Bonjardim, Leonardo Rigoldi 2 ; Sócrates Cabral de Holanda Cavalcanti 3   VIAFID ORCID Logo  ; Lucindo José Quintans Junior 2 

 Núcleo de Estudos e Pesquisas de Plantas Medicinais, Universidade Federal do Vale do São Francisco, 56.304-205 Petrolina, PE, Brazil 
 Laboratório de Farmacologia Pré-Clínica, Universidade Federal de Sergipe, 49.000-100 São Cristóvão, SE, Brazil 
 Departamento de Farmácia, Universidade Federal de Sergipe,49.000-100 São Cristóvão, SE, Brazil 
Editor
Niels Juel Christensen, Michael W Jann
Publication year
2013
Publication date
2013
Publisher
John Wiley & Sons, Inc.
ISSN
23566140
e-ISSN
1537744X
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2175217713
Copyright
Copyright © 2013 Jackson Roberto Guedes da Silva Almeida et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0/