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Myocardial infarction, in the diagnostic and therapeutic aspects, is of one of the great social and medical problems. Clinical diagnosis requires the presence of clinical symptoms in combination with indirect indicators of cardiac necrosis, such as biochemical markersenzymes, electrocardiographic (ECG) and echocardiography findings. Assessment of heart failure by determining markers of myocardial damage is very significant challenge in the process of clinical assessment of patients with myocardial infarction, for further diagnosis, treatment and prognosis. Heart failure occurs in all patients with myocardial infarction, to a lesser or greater extent. Bearing in mind that, a myocardial infarction involving the anterior wall of the heart has worse prognosis, the subject of interest of this study is whether the markers of myocardial damage will be higher in patients with this localization of myocardial infarction. It was interested too, in whether it is possible to find elevated markers of myocardial damage- failure indicators, brain natriuretic peptide, in corelation with clinical signs of cardiac insuficiency.
Key words: myocardial infarction, brain natriuretic peptide, cardiac insufficiency
Introduction: Myocardial infarction, in the diagnostic and therapeutic aspects, is of one of the great social and medical problems. Assessment of heart failure by determining markers of myocardial damage is very significant challenge in the process of clinical assessment of patients with myocardial infarction, for further diagnosis, treatment and prognosis. Heart failure occurs in all patients with myocardial infarction, to a lesser or greater extent. Bearing in mind that, a myocardial infarction involving the anterior wall of the heart has worse prognosis, the subject of interest of this study is whether the markers of myocardial damage will be higher in patients with this localization of myocardial infarction. It was interested too, in whether it is possible to find elevated markers of myocardial damage- failure indicators, brain natriuretic peptide, in corelation with clinical signs of cardiac insuficiency. By analyzing the results of research showed that people with acute myocardial infarction have elevated levels of plasma brain natriuretic peptide particular the first and fifth day from the onset of acute myocardial infarction. Patients with larger myocardial infarction, involving the anterior wall of the heart, showed a secondary increase in BNP the 5 th day after the occurrence of myocardial infarction, reflecting a process- postinfarction remodeling.
Objectives: The...