Abstract

We searched for genetic causes of major psychiatric disorders (bipolar disorder, schizoaffective disorder, and schizophrenia) in a large, densely affected pedigree from Northern Sweden that originated with three pairs of founders born around 1650. We applied a systematic genomic approach to the pedigree via karyotyping (N = 9), genome-wide SNP arrays (N = 418), whole-exome sequencing (N = 26), and whole-genome sequencing (N = 10). Comprehensive analysis did not identify plausible variants of strong effect. Rather, pedigree cases had significantly higher genetic risk scores compared to pedigree and community controls.

Details

Title
The genomics of major psychiatric disorders in a large pedigree from Northern Sweden
Author
Szatkiewicz Jin 1 ; Crowley, James J 1 ; Adolfsson, Annelie Nordin 2 ; Åberg, Karolina A 3 ; Alaerts Maaike 4 ; Genovese Giulio 5 ; McCarroll, Steven 5 ; Del-Favero, Jurgen 6 ; Adolfsson Rolf 2 ; Sullivan, Patrick F 7   VIAFID ORCID Logo 

1  University of North Carolina at Chapel Hill, Department of Genetics, Chapel Hill, USA (GRID:grid.10698.36) (ISNI:0000000122483208) 
2  University of Umeå, Department of Clinical Sciences and Psychiatry, Umeå, Sweden (GRID:grid.12650.30) (ISNI:0000 0001 1034 3451) 
3  Virginia Commonwealth University, Center for Biomarker Research and Precision Medicine, Richmond, USA (GRID:grid.224260.0) (ISNI:0000 0004 0458 8737) 
4  University of Antwerp and Antwerp University Hospital, Center of Medical Genetics, Antwerp, Belgium (GRID:grid.5284.b) (ISNI:0000 0001 0790 3681) 
5  Broad Institute of MIT and Harvard, Cambridge, USA (GRID:grid.66859.34) 
6  Universiteitsplein 1, Antwerp, Belgium and Multiplicom N.V., VIB Center for Molecular Neurology, Niel, Belgium (GRID:grid.436667.6) 
7  University of North Carolina at Chapel Hill, Department of Genetics, Chapel Hill, USA (GRID:grid.10698.36) (ISNI:0000000122483208); University of North Carolina at Chapel Hill, Department of Psychiatry, Chapel Hill, USA (GRID:grid.10698.36) (ISNI:0000000122483208); Karolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, Sweden (GRID:grid.4714.6) (ISNI:0000 0004 1937 0626) 
Publication year
2019
Publication date
Feb 2019
Publisher
Nature Publishing Group
e-ISSN
21583188
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41398-019-0414-9
ProQuest document ID
2175871639
Copyright
This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.