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Abstract
Cognitive impairment is a core feature of schizophrenia (SCH). In addition to the toxic effect of Bilirubin (BIL), it has antioxidant properties that were associated with the psychopathology and cognitive impairment of psychiatric disorders. The aim of this study was to examine the correlation of serum total BIL (TBIL) concentration with cognitive impairment in SCH patients. We recruited 34 SCH patients and 119 healthy controls (HCs) in this case-control design. Cognition was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Serum TBIL concentration was measured using the immunoturbidimetric method. Serum TBIL concentration was significantly decreased in SCH patients compared to HCs after adjusting for age, gender, and education. Serum TBIL concentration in SCH patients was also positively correlated with the RBANS immediate memory score. Further stepwise multiple regression analysis confirmed the positive association between serum TBIL concentration and immediate memory score in SCH patients. Our findings supported that the decline in serum TBIL concentration was associated with the immediate memory impairment and psychopathology of SCH.
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1 Wenzhou Medical University, Wenzhou Kangning Hospital, Zhejiang, China (GRID:grid.268099.c) (ISNI:0000 0001 0348 3990)
2 The Affiliated Guangji Hospital of Soochow University, Soochow University, Institute of Mental Health, Jiangsu, China (GRID:grid.263761.7) (ISNI:0000 0001 0198 0694); Suzhou Center for Disease Prevention and Control, Jiangsu, China (GRID:grid.263761.7)
3 The Affiliated Guangji Hospital of Soochow University, Soochow University, Institute of Mental Health, Jiangsu, China (GRID:grid.263761.7) (ISNI:0000 0001 0198 0694)
4 Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, Department of Psychiatry, East Garden City, USA (GRID:grid.263761.7); The Zucker Hillside Hospital, Northwell Health, Division of Psychiatry Research, Glen Oaks, USA (GRID:grid.440243.5)
5 Graduate School of Medicine, Gunma University, Department of Neurobiology and Behavior, Maebashi, Japan (GRID:grid.256642.1) (ISNI:0000 0000 9269 4097)
6 Mengcheng Brain Health Hospital, Anhui, China (GRID:grid.263761.7)
7 Wenzhou Medical University, Wenzhou Kangning Hospital, Zhejiang, China (GRID:grid.268099.c) (ISNI:0000 0001 0348 3990); The Affiliated Guangji Hospital of Soochow University, Soochow University, Institute of Mental Health, Jiangsu, China (GRID:grid.263761.7) (ISNI:0000 0001 0198 0694); Suzhou Center for Disease Prevention and Control, Jiangsu, China (GRID:grid.263761.7)