Abstract

Subjective

The aim of the present study was to investigate the prognostic significance of preoperative complete blood count inflammatory markers in women operated for invasive Epithelial Ovarian Cancer (EOC).

Method

Two hundred forty four patients that underwent operation with the diagnosis of invasive EOC between 2006 and 2014 were included in the study. The date of operation, date of recurrence and final mortality evaluations were performed for survival analysis. The sensitivity, specificity, PPV and NPV were separately calculated with ROC analysis. Survival analysis was carried out with Kaplan Meier-Log Rank Method.

Results

Five-years overall survival rate was 56, 9% and 5-year disease-free survival (DFS) rate was 45,5%. Advanced disease stage, moderate-poor tumor differentiation, and the presence of recurrence were determined to have significant inverse relation at mean survival and 5-year survival rates. Neutrophil/lymphocyte ratio (NLR) and Platelet lymphocyte ratio (PLR) had prognostic effect on both DFS and overall survival based upon the cut-off values determined in the study (PLR = 231, s36, NLR = 3,83). Histopathological subtypes were not found to have any prognostic value. In correlation analysis, PLR and NLR had positive correlation with each other and negative correlation with overall survival.

Conclusions

Inflammatory markers such as NLR and PLR have independent prognostic value for women who undergo surgery for invasive EOC.

Details

Title
Can complete blood count inflammatory parameters in epithelial ovarian cancer contribute to prognosis? - a survival analysis
Author
Ceran, Mehmet Ufuk; Tasdemir, Umit; Colak, Eser; Güngör, Tayfun
Publication year
2019
Publication date
2019
Publisher
BioMed Central
e-ISSN
17572215
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2183387282
Copyright
Copyright © 2019. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.