Abstract

The present study evaluated the associations between gallstones and renal stones using a national sample cohort of the Korean population. The Korean National Health Insurance Service-National Sample Cohort was collected from 2002 to 2013. We designed two different longitudinal follow-up studies. In study I, we extracted gallstone patients (n = 20,711) and 1:4-matched control I subjects (n = 82,844) and analyzed the occurrence of renal stones. In study II, we extracted renal stone patients (n = 23,615) and 1:4-matched control II subjects (n = 94,460) and analyzed the occurrence of gallstones. Matching was performed for age, sex, income, region of residence, and history of hypertension, diabetes mellitus, and dyslipidemia. Crude and adjusted hazard ratios (HRs) were calculated using a Cox proportional hazards model, and the 95% confidence intervals (CIs) were calculated. Subgroup analyses were performed according to age and sex. The adjusted HR of renal stones was 1.93 (95% CI = 1.75–2.14) in the gallstone group (P < 0.001). The adjusted HR of gallstones was 1.97 (95% CI = 1.81–2.15) in the renal stone group (P < 0.001). The results were consistent in all subgroup analyses. Gallstones increased the risk of renal stones, and renal stones increased the risk of gallstones.

Details

Title
Bidirectional association between gallstones and renal stones: Two longitudinal follow-up studies using a national sample cohort
Author
Kim So Young 1 ; Song Chang Myeon 2 ; Lim, Hyun 3 ; Lim, Man Sup 4 ; Bang Woojin 5 ; Choi, Hyo Geun 6   VIAFID ORCID Logo 

 CHA Bundang Medical Center, CHA University, Department of Otorhinolaryngology-Head & Neck Surgery, Seongnam, Korea 
 Hanyang University College of Medicine, Department of Otorhinolaryngology-Head & Neck Surgery, Seoul, Korea (GRID:grid.49606.3d) (ISNI:0000 0001 1364 9317) 
 Hallym University College of Medicine, Department of Internal Medicine, Anyang, Korea (GRID:grid.256753.0) (ISNI:0000 0004 0470 5964) 
 Hallym University College of Medicine, Department of General Surgery, Chuncheon, Korea (GRID:grid.256753.0) (ISNI:0000 0004 0470 5964) 
 Hallym University College of Medicine, Department of Urology, Anyang, Korea (GRID:grid.256753.0) (ISNI:0000 0004 0470 5964) 
 Hallym University College of Medicine, Department of Otorhinolaryngology-Head & Neck Surgery, Anyang, Korea (GRID:grid.256753.0) (ISNI:0000 0004 0470 5964) 
Publication year
2019
Publication date
Dec 2019
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2185064594
Copyright
This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.