A comparative study of the variation in coagulation profile between different blood groups in ischemic heart disease patients and normal subjects

Abstract

Shortened levels of PT and aPTT and higher levels of fibrinogen are seen in blood group A individuals. [...]it can be said that among the various risks associated with the development of IHD, ABO blood group is also one of them wherein blood group A individuals are more likely to the develop the disease while blood group O confers protection against IHD. The preformed questionnaire included a detailed history of sociodemographic data, history of presenting illness, past and family history including history of hypertension, diabetes mellitus, IHD and thyroid disorders, and personal history including type of diet and any history of addictions such as smoking history and alcohol intake was noted. PT, aPTT, and fibrinogen levels were analyzed on the venous blood samples that were collected from each subject in the Biochemistry laboratory of Basaveshwar Teaching and General Hospital on Sysmex CA-50 (Code- 461-2035-2 Sysmex Corporation Kobe, Japan) Automated Blood Coagulation Analyzer. [...]a shortened aPTT can be explained by higher levels of vWF and its accompanying Factor VIII.