It appears you don't have support to open PDFs in this web browser. To view this file, Open with your PDF reader
Abstract
Systems biology can unravel complex biology but has not been extensively applied to human newborns, a group highly vulnerable to a wide range of diseases. We optimized methods to extract transcriptomic, proteomic, metabolomic, cytokine/chemokine, and single cell immune phenotyping data from <1 ml of blood, a volume readily obtained from newborns. Indexing to baseline and applying innovative integrative computational methods reveals dramatic changes along a remarkably stable developmental trajectory over the first week of life. This is most evident in changes of interferon and complement pathways, as well as neutrophil-associated signaling. Validated across two independent cohorts of newborns from West Africa and Australasia, a robust and common trajectory emerges, suggesting a purposeful rather than random developmental path. Systems biology and innovative data integration can provide fresh insights into the molecular ontogeny of the first week of life, a dynamic developmental phase that is key for health and disease.
The first week of life impacts health for all of life, but the mechanisms are little-understood. Here the authors extract multi-omic data from small volumes of blood to study the dynamic molecular changes during the first week of life, revealing a robust developmental trajectory common to different populations.
You have requested "on-the-fly" machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Show full disclaimer
Neither ProQuest nor its licensors make any representations or warranties with respect to the translations. The translations are automatically generated "AS IS" and "AS AVAILABLE" and are not retained in our systems. PROQUEST AND ITS LICENSORS SPECIFICALLY DISCLAIM ANY AND ALL EXPRESS OR IMPLIED WARRANTIES, INCLUDING WITHOUT LIMITATION, ANY WARRANTIES FOR AVAILABILITY, ACCURACY, TIMELINESS, COMPLETENESS, NON-INFRINGMENT, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Your use of the translations is subject to all use restrictions contained in your Electronic Products License Agreement and by using the translation functionality you agree to forgo any and all claims against ProQuest or its licensors for your use of the translation functionality and any output derived there from. Hide full disclaimer
Details












1 University of British Columbia, Department of Microbiology & Immunology, Vancouver, Canada (GRID:grid.17091.3e) (ISNI:0000 0001 2288 9830)
2 PROOF Centre of Excellence, Vancouver, Canada (GRID:grid.460559.b)
3 University of British Columbia, Department of Experimental Medicine, Vancouver, Canada (GRID:grid.17091.3e) (ISNI:0000 0001 2288 9830); Telethon Kids Institute, Subiaco, Australia (GRID:grid.414659.b) (ISNI:0000 0000 8828 1230)
4 Boston Children’s Hospital, Department of Pathology, Boston, USA (GRID:grid.2515.3) (ISNI:0000 0004 0378 8438); Boston Children’s Hospital, Precision Vaccines Program, Division of Infectious Diseases, Boston, USA (GRID:grid.2515.3) (ISNI:0000 0004 0378 8438); Harvard Medical School, Boston, USA (GRID:grid.38142.3c) (ISNI:000000041936754X)
5 Boston Children’s Hospital, Precision Vaccines Program, Division of Infectious Diseases, Boston, USA (GRID:grid.2515.3) (ISNI:0000 0004 0378 8438); Harvard Medical School, Boston, USA (GRID:grid.38142.3c) (ISNI:000000041936754X)
6 Vaccines & Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Banjul, Gambia (GRID:grid.38142.3c); Medical Center of the University of Munich (LMU), Center for International Health, Munich, Germany (GRID:grid.5252.0) (ISNI:0000 0004 1936 973X)
7 University of British Columbia, Department of Pediatrics, BC Children’s Hospital, Vancouver, Canada (GRID:grid.17091.3e) (ISNI:0000 0001 2288 9830)
8 Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea (GRID:grid.417153.5) (ISNI:0000 0001 2288 2831)
9 The University of Melbourne, Statistical Genomics, School of Mathematics and Statistics, Melbourne Integrative Genomics, Centre for Systems Genomics, Parkville, Australia (GRID:grid.1008.9) (ISNI:0000 0001 2179 088X)
10 Vaccines & Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Banjul, Gambia (GRID:grid.1008.9)
11 University of British Columbia, Department of Experimental Medicine, Vancouver, Canada (GRID:grid.17091.3e) (ISNI:0000 0001 2288 9830)
12 University of British Columbia, Department of Microbiology & Immunology, Vancouver, Canada (GRID:grid.17091.3e) (ISNI:0000 0001 2288 9830); BCCA, Graduate Program in Bioinformatics, Vancouver, Canada (GRID:grid.248762.d) (ISNI:0000 0001 0702 3000)
13 Vaccines & Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Banjul, Gambia (GRID:grid.248762.d)
14 Boston Children’s Hospital, Precision Vaccines Program, Division of Infectious Diseases, Boston, USA (GRID:grid.2515.3) (ISNI:0000 0004 0378 8438)
15 Division of Paediatrics, School of Medicine, University of Western Australia, Nedlands, Australia (GRID:grid.1012.2) (ISNI:0000 0004 1936 7910); University of Western Australia Perth, Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Nedlands, Australia (GRID:grid.1012.2) (ISNI:0000 0004 1936 7910)
16 Vaccines & Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Banjul, Gambia (GRID:grid.417153.5)
17 BC Cancer Agency, Vancouver, Canada (GRID:grid.248762.d) (ISNI:0000 0001 0702 3000)
18 PROOF Centre of Excellence, Vancouver, Canada (GRID:grid.460559.b); University of British Columbia, Department of Pathology and Laboratory Medicine, Faculty of Medicine, Vancouver, Canada (GRID:grid.17091.3e) (ISNI:0000 0001 2288 9830)
19 Boston Children’s Hospital, Precision Vaccines Program, Division of Infectious Diseases, Boston, USA (GRID:grid.2515.3) (ISNI:0000 0004 0378 8438); Harvard Medical School, Boston, USA (GRID:grid.38142.3c) (ISNI:000000041936754X); Boston Children’s Hospital, Division of Newborn Medicine, Boston, USA (GRID:grid.2515.3) (ISNI:0000 0004 0378 8438)
20 Boston Children’s Hospital, Precision Vaccines Program, Division of Infectious Diseases, Boston, USA (GRID:grid.2515.3) (ISNI:0000 0004 0378 8438); University of British Columbia, Department of Medical Genetics, Vancouver, Canada (GRID:grid.17091.3e) (ISNI:0000 0001 2288 9830)
21 Institute for Medical Immunology, Université libre de Bruxelles, Gosselies, Belgium (GRID:grid.4989.c) (ISNI:0000 0001 2348 0746)
22 BC Cancer Agency, Vancouver, Canada (GRID:grid.248762.d) (ISNI:0000 0001 0702 3000); University of British Columbia, Department of Medical Genetics, Vancouver, Canada (GRID:grid.17091.3e) (ISNI:0000 0001 2288 9830)
23 Boston Children’s Hospital, Precision Vaccines Program, Division of Infectious Diseases, Boston, USA (GRID:grid.2515.3) (ISNI:0000 0004 0378 8438); Harvard Medical School, Boston, USA (GRID:grid.38142.3c) (ISNI:000000041936754X); Boston Children’s Hospital, Center for Applied Pediatric Quality Analytics, Boston, USA (GRID:grid.2515.3) (ISNI:0000 0004 0378 8438)
24 University of Western Australia Perth, Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Nedlands, Australia (GRID:grid.1012.2) (ISNI:0000 0004 1936 7910)
25 Boston Children’s Hospital, Department of Pathology, Boston, USA (GRID:grid.2515.3) (ISNI:0000 0004 0378 8438); Boston Children’s Hospital, Precision Vaccines Program, Division of Infectious Diseases, Boston, USA (GRID:grid.2515.3) (ISNI:0000 0004 0378 8438); Vaccines & Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Banjul, Gambia (GRID:grid.2515.3)
26 PROOF Centre of Excellence, Vancouver, Canada (GRID:grid.460559.b); UBC Centre for Heart and Lung Innovation, Vancouver, Canada (GRID:grid.17091.3e) (ISNI:0000 0001 2288 9830); UBC, Department of Medicine, Division of Respiratory Medicine, Vancouver, Canada (GRID:grid.17091.3e) (ISNI:0000 0001 2288 9830)
27 Vaccines & Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Banjul, Gambia (GRID:grid.17091.3e); London School of Hygiene and Tropical Medicine, The Vaccine Centre, Faculty of Infectious and Tropical Diseases, London, UK (GRID:grid.8991.9) (ISNI:0000 0004 0425 469X)
28 Boston Children’s Hospital, Precision Vaccines Program, Division of Infectious Diseases, Boston, USA (GRID:grid.2515.3) (ISNI:0000 0004 0378 8438); Harvard Medical School, Boston, USA (GRID:grid.38142.3c) (ISNI:000000041936754X); Broad Institute of MIT & Harvard, Cambridge, USA (GRID:grid.66859.34)
29 University of British Columbia, Department of Experimental Medicine, Vancouver, Canada (GRID:grid.17091.3e) (ISNI:0000 0001 2288 9830); University of British Columbia, Department of Pediatrics, BC Children’s Hospital, Vancouver, Canada (GRID:grid.17091.3e) (ISNI:0000 0001 2288 9830); Telethon Kids Institute, Subiaco, Australia (GRID:grid.414659.b) (ISNI:0000 0000 8828 1230)