Abstract

Calcitonin gene-related peptide (CGRP) is a neuropeptide with a pivotal role in the pathophysiology of migraine. Blockade of CGRP is a new therapeutic target for patients with migraine. CGRP and its receptors are distributed not only in the central and peripheral nervous system but also in the cardiovascular system, both in blood vessels and in the heart. We reviewed the current evidence on the role of CGRP in the cardiovascular system in order to understand the possible short- and long-term effect of CGRP blockade with monoclonal antibodies in migraineurs.

In physiological conditions, CGRP has important vasodilating effects and is thought to protect organs from ischemia. Despite the aforementioned cardiovascular implication, preventive treatment with CGRP antibodies has shown no relevant cardiovascular side effects. Results from long-term trials and from real life are now needed.

Details

Title
CGRP and migraine from a cardiovascular point of view: what do we expect from blocking CGRP?
Author
Favoni Valentina 1   VIAFID ORCID Logo  ; Giani Luca 2 ; Al-Hassany, Linda 3 ; Asioli, Gian Maria 1 ; Butera Calogera 4 ; de Boer Irene 5 ; Guglielmetti Martina 6 ; Koniari Chrysoula 7 ; Mavridis Theodoros 7 ; Vaikjärv Marge 8 ; Verhagen, Iris 9 ; Verzina Angela 10 ; Zick Bart 9 ; Martelletti Paolo 11 ; Sacco Simona 12 

1  University of Bologna, Department of Biomedical and Neuromotor Sciences, Bologna, Italy (GRID:grid.6292.f) (ISNI:0000 0004 1757 1758); IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy (GRID:grid.492077.f) 
2  Ricovero Ferdinando Uboldi, Paderno Dugnano, Italy (GRID:grid.492077.f) 
3  Erasmus MC, Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Rotterdam, The Netherlands (GRID:grid.5645.2) (ISNI:000000040459992X) 
4  IRCCS Ospedale San Raffaele, Dipartimento Neurologico e INSPE, Milan, Italy (GRID:grid.18887.3e) (ISNI:0000000417581884) 
5  Leiden University Medical Center, Department of Neurology, Leiden, The Netherlands (GRID:grid.10419.3d) (ISNI:0000000089452978) 
6  Sapienza University, Department of Clinical and Molecular Medicine, Rome, Italy (GRID:grid.7841.a); Sant’Andrea Hospital, Regional Referral Headache Center, Rome, Italy (GRID:grid.415230.1) (ISNI:0000 0004 1757 123X); University of Sassari, Department of Clinical Pathology, Sassari, Italy (GRID:grid.11450.31) (ISNI:0000 0001 2097 9138) 
7  Aeginition Hospital, School of Medicine, National and Kapodistrian University of Athens, 1st Neurology Department, Athens, Greece (GRID:grid.5216.0) (ISNI:0000 0001 2155 0800) 
8  University of Tartu, Faculty of Medicine, Tartu, Estonia (GRID:grid.10939.32) (ISNI:0000 0001 0943 7661) 
9  Erasmus MC, Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Rotterdam, The Netherlands (GRID:grid.5645.2) (ISNI:000000040459992X); Leiden University Medical Center, Department of Neurology, Leiden, The Netherlands (GRID:grid.10419.3d) (ISNI:0000000089452978) 
10  University of Perugia, Neurology Clinic, Perugia, Italy (GRID:grid.9027.c) (ISNI:0000 0004 1757 3630); S. Maria della Misericordia Hospital, Perugia, Italy (GRID:grid.411492.b) 
11  Sapienza University, Department of Clinical and Molecular Medicine, Rome, Italy (GRID:grid.7841.a); Sant’Andrea Hospital, Regional Referral Headache Center, Rome, Italy (GRID:grid.415230.1) (ISNI:0000 0004 1757 123X) 
12  Ospedale SS Filippo e Nicola, UOC Neurologia e Stroke Unit, Avezzano, Italy (GRID:grid.415230.1); University of L’Aquila, Department of Applied Clinical Sciences and Biotechnology, L’Aquila, Italy (GRID:grid.158820.6) (ISNI:0000 0004 1757 2611) 
Publication year
2019
Publication date
Dec 2019
Publisher
Springer Nature B.V.
ISSN
11292369
e-ISSN
11292377
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/s10194-019-0979-y
ProQuest document ID
2190922594
Copyright
The Journal of Headache and Pain is a copyright of Springer, (2019). All Rights Reserved. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.