Abstract

Noninvasive medical imaging of blood flow relies on mapping the transit of a contrast medium bolus injected intravenously. This has the draw-back that the front of the bolus widens until the tissue of interest is reached and quantitative flow parameters are not easy to obtain. Here, we introduce high resolution (millimeter/millisecond) 3D magnetic tracking of a single microsphere locally probing the flow while passing through a vessel. With this, we successfully localize and evaluate diameter constrictions in an arteria phantom after a single passage of a microsphere. We further demonstrate the potential for clinical application by tracking a microsphere smaller than a red blood cell.

Details

Title
Noninvasive monitoring of blood flow using a single magnetic microsphere
Author
Liebl Maik 1 ; Gleich Bernhard 2 ; Eberbeck Dietmar 1 ; Radon, Patricia 1 ; Rahmer Jürgen 2   VIAFID ORCID Logo  ; Trahms Lutz 1 ; Wiekhorst Frank 1 

1  Physikalisch-Technische Bundesanstalt, Berlin, Germany (GRID:grid.4764.1) (ISNI:0000 0001 2186 1887) 
2  Research Laboratories, Philips GmbH Innovative Technologies, Hamburg, Germany (GRID:grid.7468.d) (ISNI:0000 0001 2248 7639) 
Publication year
2019
Publication date
Dec 2019
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41598-019-41416-6
ProQuest document ID
2195266869
Copyright
This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.