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Copyright © 2019 Ayman M. Mahmoud et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0/

Abstract

The prevalence of cardiovascular disease (CVD) is increasing over time. CVD is a comorbidity in diabetes and contributes to premature death. Citrus flavonoids possess several biological activities and have emerged as efficient therapeutics for the treatment of CVD. Citrus flavonoids scavenge free radicals, improve glucose tolerance and insulin sensitivity, modulate lipid metabolism and adipocyte differentiation, suppress inflammation and apoptosis, and improve endothelial dysfunction. The intake of citrus flavonoids has been associated with improved cardiovascular outcomes. Although citrus flavonoids exerted multiple beneficial effects, their mechanisms of action are not completely established. In this review, we summarized recent findings and advances in understanding the mechanisms underlying the protective effects of citrus flavonoids against oxidative stress, inflammation, diabetes, dyslipidemia, endothelial dysfunction, and atherosclerosis. Further studies and clinical trials to assess the efficacy and to explore the underlying mechanism(s) of action of citrus flavonoids are recommended.

Details

Title
Beneficial Effects of Citrus Flavonoids on Cardiovascular and Metabolic Health
Author
Mahmoud, Ayman M 1   VIAFID ORCID Logo  ; Hernández Bautista, Rene J 2 ; Sandhu, Mansur A 3 ; Hussein, Omnia E 1 

 Physiology Division, Department of Zoology, Faculty of Science, Beni-Suef University, Egypt 
 Metropolitan Autonomous University, Laboratory of Bioenergetics and Cellular Aging, Department of Health Sciences, Division of Health and Biological Sciences, Mexico 
 Biomedical Sciences Department, Faculty of Veterinary & Animal Sciences, PMAS Arid Agriculture University, Pakistan 
Editor
Luigi Iuliano
Publication year
2019
Publication date
2019
Publisher
John Wiley & Sons, Inc.
ISSN
19420900
e-ISSN
19420994
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2196465691
Copyright
Copyright © 2019 Ayman M. Mahmoud et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0/