Abstract

Adhesive hydrogels have gained popularity in biomedical applications, however, traditional adhesive hydrogels often exhibit short-term adhesiveness, poor mechanical properties and lack of antibacterial ability. Here, a plant-inspired adhesive hydrogel has been developed based on Ag-Lignin nanoparticles (NPs)triggered dynamic redox catechol chemistry. Ag-Lignin NPs construct the dynamic catechol redox system, which creates long-lasting reductive-oxidative environment inner hydrogel networks. This redox system, generating catechol groups continuously, endows the hydrogel with long-term and repeatable adhesiveness. Furthermore, Ag-Lignin NPs generate free radicals and trigger self-gelation of the hydrogel under ambient environment. This hydrogel presents high toughness for the existence of covalent and non-covalent interaction in the hydrogel networks. The hydrogel also possesses good cell affinity and high antibacterial activity due to the catechol groups and bactericidal ability of Ag-Lignin NPs. This study proposes a strategy to design tough and adhesive hydrogels based on dynamic plant catechol chemistry.

Biomimetic catechol-based adhesives have attracted significant interest but can lose adhesion due to excessive oxidation. Here, the authors report on the addition of silver-Lignin nanoparticles as a dynamic catechol redox system to maintain catechol/quinone balance, making a reusable, antibacterial bioadhesive.

Details

Title
Plant-inspired adhesive and tough hydrogel based on Ag-Lignin nanoparticles-triggered dynamic redox catechol chemistry
Author
Gan Donglin 1 ; Xing Wensi 1 ; Jiang, Lili 2 ; Ju, Fang 3 ; Zhao Cancan 3 ; Ren Fuzeng 3 ; Fang Liming 4 ; Wang, Kefeng 5 ; Lu, Xiong 1   VIAFID ORCID Logo 

 Southwest Jiaotong University, Key Lab of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Chengdu, China (GRID:grid.263901.f) (ISNI:0000 0004 1791 7667) 
 Xihua University, Key Laboratory of Fluid and Power Machinery of Ministry of Education, School of Materials Science and Engineering, Chengdu, China (GRID:grid.412983.5) (ISNI:0000 0000 9427 7895) 
 Southern University of Science and Technology, Shenzhen, Department of Materials Science and Engineering, Guangdong, China (GRID:grid.412983.5) 
 South China University of Technology, Department of Polymer Science and Engineering, School of Materials Science and Engineering, Guangzhou, China (GRID:grid.79703.3a) (ISNI:0000 0004 1764 3838) 
 Sichuan University, National Engineering Research Center for Biomaterials, Chengdu, China (GRID:grid.13291.38) (ISNI:0000 0001 0807 1581) 
Publication year
2019
Publication date
Dec 2019
Publisher
Nature Publishing Group
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2202209392
Copyright
This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.