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Copyright © 2019 Zheng-Yang Chen et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0/

Abstract

With the rapid development of modern medical technology and the deterioration of living environments, cancer, the most important disease that threatens human health, has attracted increasing concerns. Although remarkable achievements have been made in tumor research during the past several decades, a series of problems such as tumor metastasis and drug resistance still need to be solved. Recently, relevant physiological changes during space exploration have attracted much attention. Thus, space exploration might provide some inspiration for cancer research. Using on ground different methods in order to simulate microgravity, structure and function of cancer cells undergo many unique changes, such as cell aggregation to form 3D spheroids, cell-cycle inhibition, and changes in migration ability and apoptosis. Although numerous better experiments have been conducted on this subject, the results are not consistent. The reason might be that different methods for simulation have been used, including clinostats, random positioning machine (RPM) and rotating wall vessel (RWV) and so on. Therefore, we review the relevant research and try to explain novel mechanisms underlying tumor cell changes under weightlessness.

Details

Title
Effect of Weightlessness on the 3D Structure Formation and Physiologic Function of Human Cancer Cells
Author
Zheng-Yang, Chen 1 ; Guo, Song 1 ; Bin-Bin, Li 2 ; Jiang, Nan 1 ; Ao, Li 2 ; Hong-Feng, Yan 3 ; He-Ming, Yang 3 ; Jin-Lian, Zhou 4 ; Cheng-Lin, Li 3 ; Cui, Yan 3   VIAFID ORCID Logo 

 Department of General Surgery, 306 Hospital of PLA, Beijing 100101, China; Department of General Surgery, 306 Hospital of PLA-Peking University Teaching Hospital, Beijing 100101, China 
 Department of General Surgery, 306 Hospital of PLA, Beijing 100101, China; Department of General Surgery, PLA 306 Clinical Hospital of Anhui Medical University, Beijing 230000, China 
 Department of General Surgery, 306 Hospital of PLA, Beijing 100101, China 
 Department of Pathology, 306 Hospital of PLA, Beijing 100101, China 
Editor
Heide Schatten
Publication year
2019
Publication date
2019
Publisher
John Wiley & Sons, Inc.
ISSN
23146133
e-ISSN
23146141
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2209476455
Copyright
Copyright © 2019 Zheng-Yang Chen et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0/