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Abstract
We conducted a surveillance among acute respiratory tract infection (ARTI) cases to define the epidemiology, clinical characteristics and genetic variations of enterovirus D68 (EV-D68) in Beijing, China from 2015 to 2017. Nasopharyngeal swabs and sputum were collected from 30 sentinel hospitals in Beijing and subjected to EV and EV-D68 detection by real-time PCR. The VP1 gene region and complete genome sequences of EV-D68 positive cases were analyzed. Of 21816 ARTI cases, 619 (2.84%) were EV positive and 42 cases were EV-D68 positive. The detection rates of EV-D68 were 0 (0/6644) in 2015, 0.53% (40/7522) in 2016 and 0.03% (2/7650) in 2017, respectively. Two peaks of EV-D68 infections occurred in late summer and early-winter. Ten cases (23.81%) with upper respiratory tract infection and 32 cases (76.19%) presented with pneumonia, including 3 cases with severe pneumonia. The phylogenetic analysis suggested 15 subclade D3 strains and 27 subclade B3 strains of EV-D68 were circulated in China from 2016 to 2017. A total of 52 amino acid polymorphisms were identified between subclades D1 and D3. These data suggest an upsurge of EV-D68 occurred in Beijing in 2016, the new subclade D3 emerged in 2016 and co-circulated with subclade B3 between 2016 and 2017.
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1 Capital Medical University, School of Public Health, Beijing, P.R. China (GRID:grid.24696.3f) (ISNI:0000 0004 0369 153X); Beijing Municipal Center for Disease Prevention and Control, Institute for immunization and prevention, Beijing, P.R. China (GRID:grid.24696.3f)
2 Beijing Municipal Center for Disease Prevention and Control, Institute for immunization and prevention, Beijing, P.R. China (GRID:grid.24696.3f)
3 Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College, MOH Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, IPB, CAMS-Foundation Mérieux, Institute of Pathogen Biology (IPB), Beijing, P.R. China (GRID:grid.12527.33) (ISNI:0000 0001 0662 3178)
4 Beijing Municipal Center for Disease Prevention and Control, Institute for immunization and prevention, Beijing, P.R. China (GRID:grid.12527.33)
5 Capital Medical University, School of Public Health, Beijing, P.R. China (GRID:grid.24696.3f) (ISNI:0000 0004 0369 153X)