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© 2019. This work is published under https://creativecommons.org/licenses/by/4.0 (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Keywords: * HLA-G * Placenta * Real-time PCR * Miscarriage Abstract Purpose: Although it has been frequently confirmed that HLA-G plays an important role in the reproduction and pregnancy, the pattern of HLA-G gene and its protein expression are rarely addressed in studies. [...]we conducted this study in regard to evaluate the HLA-G gene and its protein expression in the women's placenta with recurrent miscarriage. Conclusion: According to the obtained results, it was concluded that the decrement of HLA-G gene and protein expressions are associated with recurrent miscarriage. Since there are conflicting results from other studies, it is suggested to conduct a more comprehensive similar study with greater sample size. Recent studies revealed that HLA-G plays an important role in the pathogenesis of RM. [...]any deficiency in HLA-G expression is associated with recurrent miscarriage.29 Akhter et al showed that the expression of HLA-G in cultured EVTs cells of the subjects with RM was decreased significantly in comparison to the subjects with normal pregnancies.30 Also, similar results about decrease of HLA-G expression in EVTs cells have been suggested by various studies.31 However, the results of some other studies are not consistent with this study.32 Bhalla and colleagues evaluated the expression of HLA-G using immunohistochemistry staining in placental tissue of the subjects with RM samples compared with the healthy control group. [...]karyotyping of aborted fetus is an important issue because abortions that is resulted from genetic abnormality should not be considered as RM cases. [...]in order to obtain better and more accurate results, it is suggested to conduct studies with greater sample size, more homogene samples and more clear definition of RM.

Details

Title
The Study of HLA-G Gene and Protein Expression in Patients with Recurrent Miscarriage
Author
Mosaferi, Elnaz 1 ; Gharamaleki, Nazila Alizadeh 1 ; Farzadi, Laya 2 ; Majidi, Jafar 1 ; Babaloo, Zohreh 1 ; Kazemi, Tohid; Ramezani, Mehrnoosh; Tabatabaei, Meraj; Ahmadi, Hamid; Maleki, Leili Aghebati; Baradaran, Behzad

 Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran 
 Women Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran 
Pages
70-75
Section
Research Article
Publication year
2019
Publication date
2019
Publisher
Tabriz University of Medical Sciences
ISSN
22285881
e-ISSN
22517308
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2220144673
Copyright
© 2019. This work is published under https://creativecommons.org/licenses/by/4.0 (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.