It appears you don't have support to open PDFs in this web browser. To view this file, Open with your PDF reader
Abstract
Orexins/hypocretins are neuropeptides implicated in numerous processes, including food intake and cognition. The role of these peptides in the psychopathology of anorexia nervosa (AN) remains poorly understood. The aim of the current study was to evaluate the associations between plasma orexin-A (OXA) concentrations and neuropsychological functioning in adult women with AN, and a matched control group. Fasting plasma OXA concentrations were taken in 51 females with AN and in 51 matched healthy controls. Set-shifting was assessed using the Wisconsin Card Sorting Test (WCST), whereas decision making was measured using the Iowa Gambling Task (IGT). The AN group exhibited lower plasma OXA levels than the HC group. Lower mean scores were obtained on the IGT in AN patients. WCST perseverative errors were significantly higher in the AN group compared to HC. In both the AN and HC group, OXA levels were negatively correlated with WCST non-perseverative errors. Reduced plasma OXA concentrations were found to be associated with set-shifting impairments in AN. Taking into consideration the function of orexins in promoting arousal and cognitive flexibility, future studies should explore whether orexin partly underpins the cognitive impairments found in AN.
You have requested "on-the-fly" machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Show full disclaimer
Neither ProQuest nor its licensors make any representations or warranties with respect to the translations. The translations are automatically generated "AS IS" and "AS AVAILABLE" and are not retained in our systems. PROQUEST AND ITS LICENSORS SPECIFICALLY DISCLAIM ANY AND ALL EXPRESS OR IMPLIED WARRANTIES, INCLUDING WITHOUT LIMITATION, ANY WARRANTIES FOR AVAILABILITY, ACCURACY, TIMELINESS, COMPLETENESS, NON-INFRINGMENT, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Your use of the translations is subject to all use restrictions contained in your Electronic Products License Agreement and by using the translation functionality you agree to forgo any and all claims against ProQuest or its licensors for your use of the translation functionality and any output derived there from. Hide full disclaimer
Details







1 Bellvitge University Hospital-IDIBELL, Department of Psychiatry, Barcelona, Spain (GRID:grid.411129.e) (ISNI:0000 0000 8836 0780); Instituto Salud Carlos III (Spain), Ciber Fisiopatologia Obesidad y Nutrición, Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427)
2 Instituto Salud Carlos III (Spain), Ciber Fisiopatologia Obesidad y Nutrición, Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427); Universitat Autònoma de Barcelona, Departament de Psicobiologia i Metodologia, Barcelona, Spain (GRID:grid.7080.f)
3 Bellvitge University Hospital-IDIBELL, Department of Psychiatry, Barcelona, Spain (GRID:grid.411129.e) (ISNI:0000 0000 8836 0780)
4 Bellvitge University Hospital-IDIBELL, Department of Psychiatry, Barcelona, Spain (GRID:grid.411129.e) (ISNI:0000 0000 8836 0780); Instituto Salud Carlos III (Spain), Ciber Fisiopatologia Obesidad y Nutrición, Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427); School of Medicine, University of Barcelona, Department of Clinical Sciences, Barcelona, Spain (GRID:grid.5841.8) (ISNI:0000 0004 1937 0247)
5 Instituto Salud Carlos III (Spain), Ciber Fisiopatologia Obesidad y Nutrición, Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427); Universidad de Málaga, Hospital Clínico Virgen de la Victoria, Unidad de Gestión Clínica de Endocrinología y Nutrición, Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain (GRID:grid.10215.37) (ISNI:0000 0001 2298 7828)
6 Instituto Salud Carlos III (Spain), Ciber Fisiopatologia Obesidad y Nutrición, Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427); Complejo Hospitalario Universitario de Santiago (CHUS) and Santiago de Compostela University (USC), Molecular and Celular Endocrinology, Instituto de Investigacion Sanitaria (IDIS), Santiago de Compostela, Spain (GRID:grid.411048.8) (ISNI:0000 0000 8816 6945)
7 Instituto Salud Carlos III (Spain), Ciber Fisiopatologia Obesidad y Nutrición, Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427); Evaluation and Treatment of the University of Valencia, Department of Psychological, Personality, Valencia, Spain (GRID:grid.5338.d) (ISNI:0000 0001 2173 938X)
8 Instituto Salud Carlos III (Spain), Ciber Fisiopatologia Obesidad y Nutrición, Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427)
9 Instituto Salud Carlos III (Spain), Ciber Fisiopatologia Obesidad y Nutrición, Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427); Neuroscience Research Program Organization IMIM (Hospital del Mar Medical Research Institute), Integrated Pharmacology and Systems Neurosciences Research Group, Barcelona, Spain (GRID:grid.20522.37) (ISNI:0000 0004 1767 9005); Universitat Pompeu Fabra Barcelona, Department of Health and Experimental Sciences, Barcelona, Spain (GRID:grid.5612.0) (ISNI:0000 0001 2172 2676)
10 Instituto Salud Carlos III (Spain), Ciber Fisiopatologia Obesidad y Nutrición, Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427); Institut d’Investigació, Biomèdica de Girona (IdIBGi), Hospital Dr Josep Trueta, Department of Diabetes, Endocrinology and Nutrition, Girona, Spain (GRID:grid.411295.a) (ISNI:0000 0001 1837 4818)
11 Instituto Salud Carlos III (Spain), Ciber Fisiopatologia Obesidad y Nutrición, Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427); Clínica Universidad de Navarra, University of Navarra-IdiSNA, Metabolic Research Laboratory, Pamplona, Spain (GRID:grid.411730.0) (ISNI:0000 0001 2191 685X)
12 Bellvitge University Hospital-IDIBELL, Department of Psychiatry, Barcelona, Spain (GRID:grid.411129.e) (ISNI:0000 0000 8836 0780); School of Medicine, University of Barcelona, Department of Clinical Sciences, Barcelona, Spain (GRID:grid.5841.8) (ISNI:0000 0004 1937 0247); Instituto Salud Carlos III (Spain), CIBER Salud Mental, Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427)