Abstract

Estimates of Plasmodium falciparum migration may inform strategies for malaria elimination. Here we elucidate fine-scale parasite population structure and infer recent migration across Southeast Asia using identity-by-descent (IBD) approaches based on genome-wide single nucleotide polymorphisms called in 1722 samples from 54 districts. IBD estimates are consistent with isolation-by-distance. We observe greater sharing of larger IBD segments between artemisinin-resistant parasites versus sensitive parasites, which is consistent with the recent spread of drug resistance. Our IBD analyses reveal actionable patterns, including isolated parasite populations, which may be prioritized for malaria elimination, as well as asymmetrical migration identifying potential sources and sinks of migrating parasites.

Details

Title
Genomic structure and diversity of Plasmodium falciparum in Southeast Asia reveal recent parasite migration patterns
Author
Shetty, Amol C 1 ; Jacob, Christopher G 2 ; Huang, Fang 3 ; Yao, Li 4 ; Agrawal, Sonia 5   VIAFID ORCID Logo  ; Saunders, David L 6 ; Chanthap Lon 7 ; Fukuda, Mark M 6 ; Ringwald, Pascal 8 ; Ashley, Elizabeth A 9 ; Han, Kay Thwe 10 ; Hlaing, Tin Maung 11 ; Nyunt, Myaing M 12 ; Silva, Joana C 13   VIAFID ORCID Logo  ; Stewart, Kathleen E 14 ; Plowe, Christopher V 12 ; Timothy D O’Connor 15 ; Takala-Harrison, Shannon 16 ; Noedl, Harald 17 ; Khan, Wasif A 18 ; Newton, Paul 19 ; Kyaw, Myat P 10 ; White, Nicholas J 20 ; Dondorp, Arjen M 20 ; Day, Nicholas P 20 ; Woodrow, Charles J 20 ; Dhorda, Mehul 21 ; M Abul Faiz 22 ; Fairhurst, Rick M 23 ; Lim, Pharath 23 ; Tripura, Rupam 20 ; Mayxay, Mayfong 24 ; Ye Htut 10 ; Nosten, Francois 25 ; Aung Pyae Phyo 26 ; Pukrittayakamee, Sasithon 27 ; Tran Tinh Hien 28 ; Nguyen Thanh Thuy Nhien 28 ; Mokuolu, Olugbenga A 29 ; Fanello, Caterina I 20 ; Onyamboko, Marie A 14 

 Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA; Graduate Program in Epidemiology and Human Genetics, University of Maryland School of Medicine, Baltimore, MD, USA 
 Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK 
 National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Beijing, PR China 
 Center for Geospatial Information Science, University of Maryland, College Park, MD, USA 
 Graduate Program in Epidemiology and Human Genetics, University of Maryland School of Medicine, Baltimore, MD, USA; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA 
 Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand 
 Armed Forces Research Institute of Medical Sciences, Phnom Penh, Cambodia 
 Global Malaria Programme, World Health Organization, Geneva, Switzerland 
 Mahidol-Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK 
10  Department of Medical Research, Ministry of Health and Sports, Yangon, Myanmar 
11  Defence Services Medical Research Centre, Naypyitaw, Myanmar 
12  Duke Global Health Institute, Duke University, Durham, NC, USA 
13  Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA 
14  Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK 
15  Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA; Program in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA 
16  Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA 
17  Institute of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Vienna, Austria 
18  International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh 
19  Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK; Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Vientiane, Laos 
20  Mahidol-Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand 
21  Asia Regional Centre & EQA Programme, Worldwide Antimalarial Resistance Network, Oxford, UK 
22  Malaria Research Group and Dev Care Foundation, Dhaka, Bangladesh 
23  Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA 
24  Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Vientiane, Laos; Faculty of Postgraduate Studies, University of Health Sciences, Vientiane, Laos 
25  Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK; Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Bangkok, Thailand 
26  Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Bangkok, Thailand 
27  Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand 
28  Centre for Tropical Medicine Oxford University Clinical Research Unit Vietnam (OUCRU), Ho Chi Minh City, Vietnam 
29  Department of Paediatrics and Child Health, University of Ilorin, Ilorin, Nigeria 
Pages
1-11
Publication year
2019
Publication date
Jun 2019
Publisher
Nature Publishing Group
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2242642093
Copyright
© 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.