Abstract

Background

Chimeric antigen receptor T (CAR-T) cell therapy simultaneously against CD19 and CD22 is an attractive strategy to address the antigen escape relapse after CD19-directed CAR-T cell therapies. However, the potential of optimizing the durability of remission by this approach in patients with B cell acute lymphoblastic leukemia (B-ALL) remains a critical unanswered question so far.

Case presentation

We treated an adult patient with relapsed and refractory B-ALL after haploidentical hematopoietic stem cell transplantation (HSCT) by administering haploidentical CAR-T cells targeting both CD19 and CD22 following preparative lymphodepleting chemotherapy. This patient has remained in minimal residual disease-negative remission for more than 14 months and has been tapered off graft versus host disease prophylaxis.

Conclusions

CAR simultaneously targeting CD19 and CD22 has the potential of inducing long-term remission in patients with B-ALL.

Details

Title
Haploidentical CD19/CD22 bispecific CAR-T cells induced MRD-negative remission in a patient with relapsed and refractory adult B-ALL after haploidentical hematopoietic stem cell transplantation
Author
Jia, Hejin; Wang, Zhenguang; Wang, Yao; Liu, Yang; Dai, Hanren; Tong, Chuan; Guo, Yelei; Guo, Bo; Ti, Dongdong; Han, Xiao; Yang, Qingming; Wu, Zhiqiang; Han, Weidong
Publication year
2019
Publication date
2019
Publisher
BioMed Central
e-ISSN
17568722
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2242874566
Copyright
© 2019. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.