Abstract

Neuropathic pain is characterized by an uncertain etiology and by a poor response to common therapies. The ineffectiveness and the frequent side effects of the drugs used to counteract neuropathic pain call for the discovery of new therapeutic strategies. Laser therapy proved to be effective for reducing pain sensitivity thus improving the quality of life. However, its application parameters and efficacy in chronic pain must be further analyzed. We investigated the pain relieving and protective effect of Photobiomodulation Therapy in a rat model of compressive mononeuropathy induced by Chronic Constriction Injury of the sciatic nerve (CCI). Laser (MLS-MiS) applications started 7 days after surgery and were performed ten times over a three week period showing a reduction in mechanical hypersensitivity and spontaneous pain that started from the first laser treatment until the end of the experiment. The ex vivo analysis highlighted the protective role of laser through the myelin sheath recovery in the sciatic nerve, inhibition of iNOS expression and enhancement of EAAT-2 levels in the spinal cord. In conclusion, this study supports laser treatment as a future therapeutic strategy in patients suffering from neuropathic pain induced by trauma.

Details

Title
Effect of NIR laser therapy by MLS-MiS source against neuropathic pain in rats: in vivo and ex vivo analysis
Author
Micheli, Laura 1 ; Cialdai, Francesca 2 ; Pacini, Alessandra 3 ; Jacopo Junio Valerio Branca 3 ; Morbidelli, Lucia 4   VIAFID ORCID Logo  ; Ciccone, Valerio 4 ; Lucarini, Elena 1 ; Ghelardini, Carla 1 ; Monici, Monica 2 ; Lorenzo Di Cesare Mannelli 1   VIAFID ORCID Logo 

 Department of Neuroscience, Psychology, Drug Research and Child Health - NEUROFARBA - Pharmacology and Toxicology Section, University of Florence, Florence, Italy 
 ASAcampus Joint Laboratory, ASA Res. Div. – Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Florence, Italy 
 Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy 
 Department of Life Sciences, University of Siena, Siena, Italy 
Pages
1-10
Publication year
2019
Publication date
Jun 2019
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2247653250
Copyright
© 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.