Abstract

Background

In clinical practice, visual assessment of glucose metabolism images is often used for the diagnosis of Alzheimer’s disease (AD) through 2-[18F]-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET) scans. However, visual assessment of the characteristic AD hypometabolic pattern relies on the expertise of the reader. Therefore, user-independent pipelines are preferred to evaluate the images and to classify the subjects. Moreover, glucose consumption is highly correlated with cerebral perfusion. Regional cerebral blood flow (rCBF) images can be derived from dynamic 11C-labelled Pittsburgh Compound B PET scans, which are also used for the assessment of the deposition of amyloid-β plaques on the brain, a fundamental characteristic of AD. The aim of this study was to explore whether these rCBF PIB images could be used for diagnostic purposes through the PMOD Alzheimer’s Discrimination Tool.

Results

Both tracer relative cerebral flow (R1) and early PIB (ePIB) (20–130 s) uptake presented a good correlation when compared to FDG standardized uptake value ratio (SUVR), while ePIB (1–8 min) showed a worse correlation. All receiver operating characteristic curves exhibited a similar shape, with high area under the curve values, and no statistically significant differences were found between curves. However, R1 and ePIB (1–8 min) had the highest sensitivity, while FDG SUVR had the highest specificity.

Conclusion

rCBF images were suggested to be a good surrogate for FDG scans for diagnostic purposes considering an adjusted threshold value.

Details

Title
Diagnostic performance of regional cerebral blood flow images derived from dynamic PIB scans in Alzheimer’s disease
Author
Peretti, Débora E 1   VIAFID ORCID Logo  ; García, David Vállez 1 ; Reesink, Fransje E 2 ; Doorduin, Janine 1 ; de Jong, Bauke M 2 ; De Deyn, Peter P 3 ; Rudi A J O Dierckx 1 ; Boellaard, Ronald 1 

1  Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands 
2  Department of Neurology, Alzheimer Centrum Groningen, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands 
3  Department of Neurology, Alzheimer Centrum Groningen, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Antwerpen, Belgium 
Pages
1-9
Publication year
2019
Publication date
Jul 2019
Publisher
Springer Nature B.V.
e-ISSN
2191219X
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/s13550-019-0528-3
ProQuest document ID
2251954526
Copyright
EJNMMI Research is a copyright of Springer, (2019). All Rights Reserved., © 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.