Abstract

Context: Docosahexaenoic acid (DHA) is an omega-3 fatty acid essential for cardiovascular health, brain development, and reproductive function. Due to hydrophobicity and low DHA bioavailability, new microencapsulated DHA formulations are under development. Aim: This study aims to evaluate DHA pharmacokinetics (PKs) and biological oxidation parameters in volunteers ingesting a newly developed lutein-containing lycosomal formulation of DHA (LF-DHA). Materials and Methods: A total of 32 healthy volunteers (40–65 years old) with signs of oxidative stress (OS) and subclinical hypoxia were orally supplemented for a month with 250 mg of regular DHA (1stgroup) or a combination of lutein (7.0 mg) and zeaxanthin (1.4 mg) (2ndgroup). The third group received regular DHA (250 mg) co-ingested with lutein/zeaxanthin (7.0/1.4 mg), whereas the 4thgroup was given LF-DHA containing lutein/zeaxanthin (7.0/1.4 mg). PK, OS, and oxygenation parameters were analyzed. Results: LF-DHA improved the PKs of DHA enhancing its serum concentrations time dependently by 34.6% and 94.1% after 2ndand 4thweeks, respectively. DHA and lutein ingested either alone or simultaneously as two separate formulations reduced the levels of OS markers. However, LF-DHA inhibited the malonicdialdehyde (MDA) and oxidized low-density lipoprotein values were better than other formulations. LF-DHA also enhanced the plasma oxygen and tissue oxygen saturation. This effect was significantly higher than in other groups. Conclusion: LF-DHA eliminates the need in high-dose DHA supplementation protocols and confers a higher DHA bioavailability, thereby improving the parameters of biological oxidation and tissue respiration in affected individuals.

Details

Title
Pharmacokinetics and oxidation parameters in volunteers supplemented with microencapsulated docosahexaenoic acid
Author
Petyaev, Ivan 1 ; Chalyk, Natalya 2 ; Klochkov, Victor 2 ; Pristensky, Dmitry 1 ; Chernyshova, Marina 1 ; Kyle, Nigel 1 ; Bashmakov, Yuriy 1 

 Lycotec Limited, Granta Park Campus, Cambridgeshire 
 Department of Clinical Cardiology, Institute of Cardiology, Saratov 
Pages
148-154
Publication year
2018
Publication date
Jul-Sep 2018
Publisher
Medknow Publications & Media Pvt. Ltd.
ISSN
2229516X
e-ISSN
22489606
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2255745341
Copyright
© 2018. This work is published under https://creativecommons.org/licenses/by-nc-sa/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.