Abstract

Reinius and Sandberg (2019) have recently shown that X-linked balletic gene expression decreases during human preimplantation embryonic development, corroborating their previous hypothesis of X dampening as a mechanism of dosage compensation. Here we demonstrate that their analyses are based on biologically false premises, thus not demonstrating the phenomena of X dampening in humans.

Details

Title
Response to "Expression reduction of biallelically transcribed X-linked genes during the female human preimplantation development."
Author
Joana Carvalho Moreira De Mello; Vibranovski, Maria D; Pereira, Lygia V
University/institution
Cold Spring Harbor Laboratory Press
Section
Contradictory Results
Publication year
2019
Publication date
Jul 18, 2019
Publisher
Cold Spring Harbor Laboratory Press
ISSN
2692-8205
Source type
Working Paper
Language of publication
English
DOI
https://doi.org/10.1101/701227
ProQuest document ID
2259822323
Copyright
© 2019. This article is published under http://creativecommons.org/licenses/by-nd/4.0/ (“the License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.