Abstract

Circular RNAs (circRNAs) are identified as vital regulators in a variety of cancers. However, the role of circRNA in lung squamous cell carcinoma (LUSC) remains largely unknown. Herein, we explore the expression profiles of circRNA and mRNA in 5 paired samples of LUSC. By analyzing the co-expression network of differentially expressed circRNAs and dysregulated mRNAs, we identify that a cell cycle-related circRNA, circTP63, is upregulated in LUSC tissues and its upregulation is correlated with larger tumor size and higher TNM stage in LUSC patients. Elevated circTP63 promotes cell proliferation both in vitro and in vivo. Mechanistically, circTP63 shares miRNA response elements with FOXM1. circTP63 competitively binds to miR-873-3p and prevents miR-873-3p to decrease the level of FOXM1, which upregulates CENPA and CENPB, and finally facilitates cell cycle progression.

Details

Title
circTP63 functions as a ceRNA to promote lung squamous cell carcinoma progression by upregulating FOXM1
Author
Cheng, Zhuoan 1 ; Yu, Chengtao 1 ; Cui, Shaohua 2 ; Wang, Hui 3 ; Jin, Haojie 3 ; Wang, Cun 3 ; Li, Botai 1 ; Qin, Meilin 3 ; Chen, Yang 4 ; He, Jia 3 ; Zuo, Qiaozhu 3 ; Wang, Siying 3 ; Liu, Jun 2   VIAFID ORCID Logo  ; Ye, Weidong 5 ; Lv, Yuanyuan 3 ; Zhao, Fangyu 3 ; Yao, Ming 3 ; Jiang, Liyan 2 ; Qin, Wenxin 6   VIAFID ORCID Logo 

1  State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Biomedical Engineering, Shanghai, China 
2  Department of Respiratory Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China 
3  Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China 
4  Shanghai Medical College of Fudan University, Shanghai, China 
5  Department of General Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China 
6  State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Biomedical Engineering, Shanghai, China; Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China 
Pages
1-13
Publication year
2019
Publication date
Jul 2019
Publisher
Nature Publishing Group
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41467-019-11162-4
ProQuest document ID
2260416709
Copyright
© 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.