Abstract

Frailty is a common syndrome in older individuals that is associated with poor cognitive outcome. The underlying brain correlates of frailty are unclear. The aim of this study was to investigate the association between frailty and MRI features of cerebral small vessel disease in a group of non-demented older individuals. We included 170 participants who were classified as frail (n = 30), pre-frail (n = 85) or non-frail (n = 55). The association of frailty and white matter hyperintensity volume and shape features, lacunar infarcts and cerebral perfusion was investigated by regression analyses adjusted for age and sex. Frail and pre-frail participants were older, more often female and showed higher white matter hyperintensity volume (0.69 [95%-CI 0.08 to 1.31], p = 0.03 respectively 0.43 [95%-CI: 0.04 to 0.82], p = 0.03) compared to non-frail participants. Frail participants showed a non-significant trend, and pre-frail participants showed a more complex shape of white matter hyperintensities (concavity index: 0.04 [95%-CI: 0.03 to 0.08], p = 0.03; fractal dimensions: 0.07 [95%-CI: 0.00 to 0.15], p = 0.05) compared to non-frail participants. No between group differences were found in gray matter perfusion or in the presence of lacunar infarcts. In conclusion, increased white matter hyperintensity volume and a more complex white matter hyperintensity shape may be structural brain correlates of the frailty phenotype.

Details

Title
The association between frailty and MRI features of cerebral small vessel disease
Author
Kant, Ilse M J 1 ; Henri J M M Mutsaerts 2   VIAFID ORCID Logo  ; Simone J T van Montfort 3 ; Jaarsma-Coes, Myriam G 4 ; Witkamp, Theodoor D 2 ; Winterer, Georg 5 ; Spies, Claudia D 6   VIAFID ORCID Logo  ; Hendrikse, Jeroen 2 ; Slooter, Arjen J C 3 ; de Bresser, Jeroen 7   VIAFID ORCID Logo  ; Armbruster, Franz Paul 8 ; Böcher, Axel 8 ; Boraschi, Diana 9 ; Borchers, Friedrich 6 ; Giacomo Della Camera 9 ; Edwin van Dellen 10 ; Diehl, Ina 8 ; Thomas Bernd Dschietzig 8 ; Feinkohl, Insa 11 ; Fillmer, Ariane 12 ; Gallinat, Jürgen 13 ; Hafen, Bettina 8 ; Hartmann, Katarina 8 ; Heidtke, Karsten 14 ; Helmschrodt, Anja 8 ; Italiani, Paola 9 ; Ittermann, Bernd 12 ; Krause, Roland 15 ; Kronabel, Marion 9 ; Kühn, Simone 16 ; Lachmann, Gunnar 6 ; Melillo, Daniela 9 ; Menon, David K 17 ; Moreno-López, Laura 17 ; Mörgeli, Rudolf 6 ; Nürnberg, Peter 14 ; Ofosu, Kwaku 6 ; Olbert, Maria 6 ; Pietzsch, Malte 18 ; Pischon, Tobias 11 ; Preller, Jacobus 19 ; Ruppert, Jana 8 ; Schneider, Reinhard 15 ; Stamatakis, Emmanuel A 17 ; Weber, Simon 18 ; Weyer, Marius 8 ; Winzeck, Stefan 12 ; Wolf, Alissa 6 ; Yürek, Fatima 6 ; Zacharias, Norman 6 

1  Department of Intensive Care Medicine and Brain Center Rudolf Magnus, UMC Utrecht, Utrecht University, Heidelberglaan 100, Utrecht, The Netherlands; Department of Radiology and Brain Center Rudolf Magnus, UMC Utrecht, Utrecht University, Heidelberglaan 100, Utrecht, The Netherlands 
2  Department of Radiology and Brain Center Rudolf Magnus, UMC Utrecht, Utrecht University, Heidelberglaan 100, Utrecht, The Netherlands 
3  Department of Intensive Care Medicine and Brain Center Rudolf Magnus, UMC Utrecht, Utrecht University, Heidelberglaan 100, Utrecht, The Netherlands 
4  Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands 
5  Experimental and Clinical Research Center (ECRC), Charité – Universitätsmedizin Berlin, Berlin, Germany; PharmaImage Biomarker Solutions GmbH, Berlin, Germany; Department of Anesthesiology and Operative Intensive Care Medicine (CCM,CVK), Charité – Universitätsmedizin Berlin, and corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany 
6  Department of Anesthesiology and Operative Intensive Care Medicine (CCM,CVK), Charité – Universitätsmedizin Berlin, and corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany 
7  Department of Radiology and Brain Center Rudolf Magnus, UMC Utrecht, Utrecht University, Heidelberglaan 100, Utrecht, The Netherlands; Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands 
8  Immundiagnostik AG, Stubenwald-Allee 8a, Bensheim, Germany 
9  National Research Council, Institute of Protein Biochemistry, Napoli, Italy 
10  Department of Psychiatry and UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands 
11  Molecular Epidemiology Research Group, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany 
12  Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Braunschweig, Germany 
13  Clinic and Policlinic of Psychiatry and Psychotherapy, University Medical Center, Hamburg-Eppendorf, Germany 
14  ATLAS Biolabs GmbH, Berlin, Germany 
15  University of Luxembourg, Luxembourg Centre for Systems Biomedicine, Luxembourg, Luxembourg 
16  Clinic and Policlinic of Psychiatry and Psychotherapy, University Medical Center, Hamburg-Eppendorf, Lise Meitner Group for Environmental Neuroscience, Max Planck Institute for Human Development, Berlin, Germany 
17  Division of Anaesthesia, Department of Medicine, University Of Cambridge, Cambridge, UK 
18  Cellogic GmbH, Niedstrasse 21, Berlin, Germany 
19  Cambridge University Hospitals NHS trust, Addenbrooke’s Hospital, Cambridge, UK 
Pages
1-9
Publication year
2019
Publication date
Aug 2019
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41598-019-47731-2
ProQuest document ID
2268790118
Copyright
© 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.