Details
Title
Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes
Author
Wang, Heming 1
; Lane, Jacqueline M 2 ; Jones, Samuel E 3
; Dashti, Hassan S 2
; Ollila, Hanna M 4 ; Wood, Andrew R 3 ; van Hees, Vincent T 5
; Brumpton, Ben 6
; Winsvold, Bendik S 7
; Kantojärvi, Katri 8 ; Palviainen, Teemu 9
; Cade, Brian E 1 ; Sofer, Tamar 1
; Song, Yanwei 10
; Patel, Krunal 10 ; Anderson, Simon G 11
; Bechtold, David A 12
; Bowden, Jack 13 ; Emsley, Richard 12 ; Kyle, Simon D 14 ; Little, Max A 15 ; Loudon, Andrew S 12 ; Frank A J L Scheer 1
; Purcell, Shaun M 1 ; Richmond, Rebecca C 16
; Spiegelhalder, Kai 17 ; Tyrrell, Jessica 3
; Zhu, Xiaofeng 18 ; Hublin, Christer 19 ; Kaprio, Jaakko A 19
; Kristiansson, Kati 20
; Sulkava, Sonja 8 ; Paunio, Tiina 8 ; Hveem, Kristian 21 ; Nielsen, Jonas B 22 ; Willer, Cristen J 22
; John-Anker Zwart 23 ; Strand, Linn B 24 ; Frayling, Timothy M 3 ; Ray, David 25 ; Lawlor, Deborah A 13
; Rutter, Martin K 26 ; Weedon, Michael N 3 ; Redline, Susan 27 ; Saxena, Richa 28
1 Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
2 Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
3 Genetics of Complex Traits, University of Exeter Medical School, Exeter, United Kingdom
4 Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA; Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland
5 Netherlands eScience Center, Amsterdam, Netherlands
6 K.G. Jebsen Centre for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK; Department of Thoracic and Occupational Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway
7 K.G. Jebsen Centre for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway; Division of Clinical Neuroscience, Oslo University Hospital and University of Oslo, Oslo, Norway
8 Genomics and Biomarkers Unit, National Institute for Health and Welfare, Helsinki, Finland; Department of Psychiatry and SleepWell Research Program, Faculty of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
9 Institute for Molecular Medicine FIMM, HiLIFE, University of Helsinki, Helsinki, Finland
10 Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA; Northeastern University College of Science, Boston, MA, USA
11 Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK; The George Alleyne Chronic Disease Research Centre, Caribbean Institute for Health Research, University of the West Indies, Cave Hill, Barbados
12 Division of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
13 MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK
14 Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
15 Department of Mathematics, Aston University, Birmingham, UK; Media Lab, Massachusetts Institute of Technology, Cambridge, MA, USA
16 MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK; School of Social and Community Medicine, University of Bristol, Bristol, UK
17 Clinic for Psychiatry and Psychotherapy, Medical Centre, University of Freiburg, Freiburg, Germany
18 Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA
19 Institute for Molecular Medicine FIMM, HiLIFE, University of Helsinki, Helsinki, Finland; Department of Public Health, University of Helsinki, Helsinki, Finland
20 Genomics and Biomarkers Unit, National Institute for Health and Welfare, Helsinki, Finland
21 K.G. Jebsen Centre for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK
22 Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA
23 Division of Clinical Neuroscience, Oslo University Hospital and University of Oslo, Oslo, Norway
24 K.G. Jebsen Centre for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway
25 NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK
26 Division of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK; Manchester Diabetes Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK
27 Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA; Department of Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
28 Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
; Lane, Jacqueline M 2 ; Jones, Samuel E 3
; Dashti, Hassan S 2
; Ollila, Hanna M 4 ; Wood, Andrew R 3 ; van Hees, Vincent T 5
; Brumpton, Ben 6
; Winsvold, Bendik S 7
; Kantojärvi, Katri 8 ; Palviainen, Teemu 9
; Cade, Brian E 1 ; Sofer, Tamar 1
; Song, Yanwei 10
; Patel, Krunal 10 ; Anderson, Simon G 11
; Bechtold, David A 12
; Bowden, Jack 13 ; Emsley, Richard 12 ; Kyle, Simon D 14 ; Little, Max A 15 ; Loudon, Andrew S 12 ; Frank A J L Scheer 1
; Purcell, Shaun M 1 ; Richmond, Rebecca C 16
; Spiegelhalder, Kai 17 ; Tyrrell, Jessica 3
; Zhu, Xiaofeng 18 ; Hublin, Christer 19 ; Kaprio, Jaakko A 19
; Kristiansson, Kati 20
; Sulkava, Sonja 8 ; Paunio, Tiina 8 ; Hveem, Kristian 21 ; Nielsen, Jonas B 22 ; Willer, Cristen J 22
; John-Anker Zwart 23 ; Strand, Linn B 24 ; Frayling, Timothy M 3 ; Ray, David 25 ; Lawlor, Deborah A 13
; Rutter, Martin K 26 ; Weedon, Michael N 3 ; Redline, Susan 27 ; Saxena, Richa 28
1 Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
2 Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
3 Genetics of Complex Traits, University of Exeter Medical School, Exeter, United Kingdom
4 Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA; Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland
5 Netherlands eScience Center, Amsterdam, Netherlands
6 K.G. Jebsen Centre for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK; Department of Thoracic and Occupational Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway
7 K.G. Jebsen Centre for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway; Division of Clinical Neuroscience, Oslo University Hospital and University of Oslo, Oslo, Norway
8 Genomics and Biomarkers Unit, National Institute for Health and Welfare, Helsinki, Finland; Department of Psychiatry and SleepWell Research Program, Faculty of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
9 Institute for Molecular Medicine FIMM, HiLIFE, University of Helsinki, Helsinki, Finland
10 Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA; Northeastern University College of Science, Boston, MA, USA
11 Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK; The George Alleyne Chronic Disease Research Centre, Caribbean Institute for Health Research, University of the West Indies, Cave Hill, Barbados
12 Division of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
13 MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK
14 Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
15 Department of Mathematics, Aston University, Birmingham, UK; Media Lab, Massachusetts Institute of Technology, Cambridge, MA, USA
16 MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK; School of Social and Community Medicine, University of Bristol, Bristol, UK
17 Clinic for Psychiatry and Psychotherapy, Medical Centre, University of Freiburg, Freiburg, Germany
18 Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA
19 Institute for Molecular Medicine FIMM, HiLIFE, University of Helsinki, Helsinki, Finland; Department of Public Health, University of Helsinki, Helsinki, Finland
20 Genomics and Biomarkers Unit, National Institute for Health and Welfare, Helsinki, Finland
21 K.G. Jebsen Centre for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK
22 Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA
23 Division of Clinical Neuroscience, Oslo University Hospital and University of Oslo, Oslo, Norway
24 K.G. Jebsen Centre for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway
25 NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK
26 Division of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK; Manchester Diabetes Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK
27 Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA; Department of Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
28 Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Pages
1-12
Publication year
2019
Publication date
Aug 2019
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2272720559
Copyright
© 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.