Details
Title
A meta-analysis of genome-wide association studies identifies multiple longevity genes
Author
Deelen, Joris 1
; Evans, Daniel S 2 ; Arking, Dan E 3 ; Tesi, Niccolò 4
; Nygaard, Marianne 5
; Liu, Xiaomin 6
; Wojczynski, Mary K 7 ; Biggs, Mary L 8 ; van der Spek, Ashley 9
; Atzmon, Gil 10 ; Ware, Erin B 11
; Sarnowski, Chloé 12 ; Smith, Albert V 13 ; Seppälä, Ilkka 14
; Cordell, Heather J 15
; Dose, Janina 16 ; Amin, Najaf 9 ; Arnold, Alice M 17 ; Ayers, Kristin L 18 ; Barzilai, Nir 19 ; Becker, Elizabeth J 20 ; Beekman, Marian 21
; Blanché, Hélène 22
; Christensen, Kaare 23
; Christiansen, Lene 24 ; Collerton, Joanna C 25 ; Cubaynes, Sarah 26 ; Cummings, Steven R 2 ; Davies, Karen 27 ; Debrabant, Birgit 28 ; Deleuze, Jean-François 29 ; Duncan, Rachel 30 ; Faul, Jessica D 11 ; Franceschi, Claudio 31 ; Galan, Pilar 32
; Gudnason, Vilmundur 33
; Harris, Tamara B 34 ; Huisman, Martijn 35 ; Hurme, Mikko A 36 ; Jagger, Carol 30
; Jansen, Iris 37 ; Jylhä, Marja 38 ; Kähönen, Mika 39 ; Karasik, David 40
; Kardia, Sharon L R 41 ; Kingston, Andrew 30 ; Kirkwood, Thomas B L 42 ; Launer, Lenore J 34 ; Lehtimäki, Terho 14 ; Lieb, Wolfgang 43 ; Leo-Pekka Lyytikäinen 14 ; Martin-Ruiz, Carmen 27
; Min, Junxia 44 ; Nebel, Almut 16 ; Newman, Anne B 45
; Nie, Chao 46 ; Nohr, Ellen A 47 ; Orwoll, Eric S 48
; Perls, Thomas T 49 ; Province, Michael A 7 ; Psaty, Bruce M 50 ; Raitakari, Olli T 51 ; Reinders, Marcel J T 52
; Robine, Jean-Marie 53
; Rotter, Jerome I 54
; Sebastiani, Paola 12 ; Smith, Jennifer 55
; Sørensen, Thorkild I A 56
; Taylor, Kent D 57
; Uitterlinden, André G 58
; Wiesje van der Flier 59 ; Sven J van der Lee 60
; van Duijn, Cornelia M 61 ; Diana van Heemst 62 ; Vaupel, James W 63 ; Weir, David 11
; Ye, Kenny 64
; Zeng, Yi 65 ; Zheng, Wanlin 2 ; Henne Holstege 4 ; Kiel, Douglas P 66
; Lunetta, Kathryn L 12
; P Eline Slagboom 21 ; Murabito, Joanne M 67
1 Max Planck Institute for Biology of Ageing, Cologne, Germany; Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands
2 California Pacific Medical Center Research Institute, San Francisco, CA, USA
3 McKusick-Nathans Institute of Genetic Medicine, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
4 Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands; Department of Clinical Genetics, Amsterdam UMC, Amsterdam, The Netherlands; Delft Bioinformatics Lab, Delft University of Technology, Delft, The Netherlands
5 The Danish Aging Research Center, Department of Public Health, University of Southern Denmark, Odense C, Denmark
6 BGI-Shenzhen, Shenzhen, China; China National Genebank, BGI-Shenzhen, Shenzhen, China
7 Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, Saint Louis, MO, USA
8 Department of Biostatistics, University of Washington, Seattle, WA, USA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA
9 Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands
10 Department of Biology, Faculty of Natural Science, University of Haifa, Haifa, Israel; Departments of Medicine and Genetics, Albert Einstein College of Medicine, Bronx, NY, USA
11 Institute for Social Research, Survey Research Center, University of Michigan, Ann Arbor, MI, USA
12 Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
13 School of Public Health, Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA; Icelandic Heart Association, Kópavogur, Iceland
14 Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center—Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
15 Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK
16 Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany
17 Department of Biostatistics, University of Washington, Seattle, WA, USA
18 Sema4, a Mount Sinai venture, Stamford, CT, USA
19 Departments of Medicine and Genetics, Albert Einstein College of Medicine, Bronx, NY, USA
20 Bioinformatics Program, Boston University, Boston, MA, USA
21 Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands
22 Fondation Jean Dausset—CEPH, Paris, France
23 The Danish Aging Research Center, Department of Public Health, University of Southern Denmark, Odense C, Denmark; Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense C, Denmark; Department of Clinical Genetics, Odense University Hospital, Odense C, Denmark
24 The Danish Aging Research Center, Department of Public Health, University of Southern Denmark, Odense C, Denmark; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
25 Institute of Health & Society, Newcastle University, Newcastle upon Tyne, UK
26 MMDN, Univ. Montpellier, EPHE, Unité Inserm 1198, PSL Research University, Montpellier, France
27 Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK
28 Department of Public Health, University of Southern Denmark, Odense C, Denmark
29 Fondation Jean Dausset—CEPH, Paris, France; Centre National de Recherche en Génomique Humaine, CEA-Institut de Biologie François Jacob, Evry, France
30 Institute of Health & Society, Newcastle University, Newcastle upon Tyne, UK; Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne, UK
31 Department of Applied Mathematics and Centre of Bioinformatics, Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia; IRCCS Institute of Neurological Sciences of Bologna (ISNB), Bologna, Italy
32 EREN, UMR U1153 Inserm/U1125 Inra/Cnam/Paris 13, Université Paris 13, CRESS, Bobigny, France
33 Icelandic Heart Association, Kópavogur, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, Iceland
34 Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, MD, USA
35 Department of Epidemiology and Biostatistics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands; Amsterdam Public Health Research Institute, Amsterdam, The Netherlands
36 Department of Microbiology and Immunology, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
37 Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
38 Faculty of Social Sciences (Health Sciences) and Gerontology Research Center (GEREC), Tampere University, Tampere, Finland
39 Department of Clinical Physiology, Tampere University Hospital and Finnish Cardiovascular Research Center—Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
40 Azrieli Faculty of Medicine, Bar Ilan University, Safed, Israel; Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA
41 School of Public Health, Epidemiology, University of Michigan, Ann Arbor, MI, USA
42 Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne, UK
43 Institute of Epidemiology and Biobank PopGen, Kiel University, Kiel, Germany
44 Institute of Translational Medicine, School of Medicine, Zhejiang University, Hangzhou, China
45 Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
46 BGI-Shenzhen, Shenzhen, China
47 Research Unit of Gynecology and Obstetrics, Department of Clinical Research, University of Southern Denmark, Odense C, Denmark
48 Bone and Mineral Unit, Oregon Health Sciences University, Portland, OR, USA
49 Department of Medicine, Geriatrics Section, Boston Medical Center, Boston University School of Medicine, Boston, MA, USA
50 Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA; Department of Health Services, University of Washington, Seattle, WA, USA; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA
51 Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
52 Delft Bioinformatics Lab, Delft University of Technology, Delft, The Netherlands
53 MMDN, Univ. Montpellier, EPHE, Unité Inserm 1198, PSL Research University, Montpellier, France; CERMES3, UMR CNRS 8211—Unité Inserm 988—EHESS—Université Paris Descartes, Paris, France
54 Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA; Division of Genetic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA
55 Institute for Social Research, Survey Research Center, University of Michigan, Ann Arbor, MI, USA; School of Public Health, Epidemiology, University of Michigan, Ann Arbor, MI, USA
56 Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, and Department of Public Health, Section of Epidemiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N, Denmark; MRC Integrative Epidemiology Unit, Bristol University, Bristol, UK
57 Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA; Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA
58 Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands; Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
59 Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands; Department of Epidemiology and Biostatistics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
60 Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands; Department of Clinical Genetics, Amsterdam UMC, Amsterdam, The Netherlands
61 Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands; Nuffield Department of Population Health, University of Oxford, Oxford, UK
62 Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
63 Max Planck Institute for Demographic Research, Rostock, Germany
64 Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA
65 Center for Healthy Aging and Development Studies, National School of Development and Raissun Institute for Advanced Studies, Peking University, Beijing, China; Center for the Study of Aging and Human Development and Geriatrics Division, Medical School of Duke University, Durham, NC, USA
66 Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA; Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA; Broad Institute of MIT & Harvard, Cambridge, MA, USA
67 NHLBI’s and Boston University’s Framingham Heart Study, Framingham, MA, USA; Section of General Internal Medicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA
; Evans, Daniel S 2 ; Arking, Dan E 3 ; Tesi, Niccolò 4
; Nygaard, Marianne 5
; Liu, Xiaomin 6
; Wojczynski, Mary K 7 ; Biggs, Mary L 8 ; van der Spek, Ashley 9
; Atzmon, Gil 10 ; Ware, Erin B 11
; Sarnowski, Chloé 12 ; Smith, Albert V 13 ; Seppälä, Ilkka 14
; Cordell, Heather J 15
; Dose, Janina 16 ; Amin, Najaf 9 ; Arnold, Alice M 17 ; Ayers, Kristin L 18 ; Barzilai, Nir 19 ; Becker, Elizabeth J 20 ; Beekman, Marian 21
; Blanché, Hélène 22
; Christensen, Kaare 23
; Christiansen, Lene 24 ; Collerton, Joanna C 25 ; Cubaynes, Sarah 26 ; Cummings, Steven R 2 ; Davies, Karen 27 ; Debrabant, Birgit 28 ; Deleuze, Jean-François 29 ; Duncan, Rachel 30 ; Faul, Jessica D 11 ; Franceschi, Claudio 31 ; Galan, Pilar 32
; Gudnason, Vilmundur 33
; Harris, Tamara B 34 ; Huisman, Martijn 35 ; Hurme, Mikko A 36 ; Jagger, Carol 30
; Jansen, Iris 37 ; Jylhä, Marja 38 ; Kähönen, Mika 39 ; Karasik, David 40
; Kardia, Sharon L R 41 ; Kingston, Andrew 30 ; Kirkwood, Thomas B L 42 ; Launer, Lenore J 34 ; Lehtimäki, Terho 14 ; Lieb, Wolfgang 43 ; Leo-Pekka Lyytikäinen 14 ; Martin-Ruiz, Carmen 27
; Min, Junxia 44 ; Nebel, Almut 16 ; Newman, Anne B 45
; Nie, Chao 46 ; Nohr, Ellen A 47 ; Orwoll, Eric S 48
; Perls, Thomas T 49 ; Province, Michael A 7 ; Psaty, Bruce M 50 ; Raitakari, Olli T 51 ; Reinders, Marcel J T 52
; Robine, Jean-Marie 53
; Rotter, Jerome I 54
; Sebastiani, Paola 12 ; Smith, Jennifer 55
; Sørensen, Thorkild I A 56
; Taylor, Kent D 57
; Uitterlinden, André G 58
; Wiesje van der Flier 59 ; Sven J van der Lee 60
; van Duijn, Cornelia M 61 ; Diana van Heemst 62 ; Vaupel, James W 63 ; Weir, David 11
; Ye, Kenny 64
; Zeng, Yi 65 ; Zheng, Wanlin 2 ; Henne Holstege 4 ; Kiel, Douglas P 66
; Lunetta, Kathryn L 12
; P Eline Slagboom 21 ; Murabito, Joanne M 67 1 Max Planck Institute for Biology of Ageing, Cologne, Germany; Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands
2 California Pacific Medical Center Research Institute, San Francisco, CA, USA
3 McKusick-Nathans Institute of Genetic Medicine, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
4 Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands; Department of Clinical Genetics, Amsterdam UMC, Amsterdam, The Netherlands; Delft Bioinformatics Lab, Delft University of Technology, Delft, The Netherlands
5 The Danish Aging Research Center, Department of Public Health, University of Southern Denmark, Odense C, Denmark
6 BGI-Shenzhen, Shenzhen, China; China National Genebank, BGI-Shenzhen, Shenzhen, China
7 Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, Saint Louis, MO, USA
8 Department of Biostatistics, University of Washington, Seattle, WA, USA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA
9 Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands
10 Department of Biology, Faculty of Natural Science, University of Haifa, Haifa, Israel; Departments of Medicine and Genetics, Albert Einstein College of Medicine, Bronx, NY, USA
11 Institute for Social Research, Survey Research Center, University of Michigan, Ann Arbor, MI, USA
12 Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
13 School of Public Health, Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA; Icelandic Heart Association, Kópavogur, Iceland
14 Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center—Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
15 Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK
16 Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany
17 Department of Biostatistics, University of Washington, Seattle, WA, USA
18 Sema4, a Mount Sinai venture, Stamford, CT, USA
19 Departments of Medicine and Genetics, Albert Einstein College of Medicine, Bronx, NY, USA
20 Bioinformatics Program, Boston University, Boston, MA, USA
21 Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands
22 Fondation Jean Dausset—CEPH, Paris, France
23 The Danish Aging Research Center, Department of Public Health, University of Southern Denmark, Odense C, Denmark; Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense C, Denmark; Department of Clinical Genetics, Odense University Hospital, Odense C, Denmark
24 The Danish Aging Research Center, Department of Public Health, University of Southern Denmark, Odense C, Denmark; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
25 Institute of Health & Society, Newcastle University, Newcastle upon Tyne, UK
26 MMDN, Univ. Montpellier, EPHE, Unité Inserm 1198, PSL Research University, Montpellier, France
27 Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK
28 Department of Public Health, University of Southern Denmark, Odense C, Denmark
29 Fondation Jean Dausset—CEPH, Paris, France; Centre National de Recherche en Génomique Humaine, CEA-Institut de Biologie François Jacob, Evry, France
30 Institute of Health & Society, Newcastle University, Newcastle upon Tyne, UK; Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne, UK
31 Department of Applied Mathematics and Centre of Bioinformatics, Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia; IRCCS Institute of Neurological Sciences of Bologna (ISNB), Bologna, Italy
32 EREN, UMR U1153 Inserm/U1125 Inra/Cnam/Paris 13, Université Paris 13, CRESS, Bobigny, France
33 Icelandic Heart Association, Kópavogur, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, Iceland
34 Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, MD, USA
35 Department of Epidemiology and Biostatistics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands; Amsterdam Public Health Research Institute, Amsterdam, The Netherlands
36 Department of Microbiology and Immunology, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
37 Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
38 Faculty of Social Sciences (Health Sciences) and Gerontology Research Center (GEREC), Tampere University, Tampere, Finland
39 Department of Clinical Physiology, Tampere University Hospital and Finnish Cardiovascular Research Center—Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
40 Azrieli Faculty of Medicine, Bar Ilan University, Safed, Israel; Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA
41 School of Public Health, Epidemiology, University of Michigan, Ann Arbor, MI, USA
42 Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne, UK
43 Institute of Epidemiology and Biobank PopGen, Kiel University, Kiel, Germany
44 Institute of Translational Medicine, School of Medicine, Zhejiang University, Hangzhou, China
45 Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
46 BGI-Shenzhen, Shenzhen, China
47 Research Unit of Gynecology and Obstetrics, Department of Clinical Research, University of Southern Denmark, Odense C, Denmark
48 Bone and Mineral Unit, Oregon Health Sciences University, Portland, OR, USA
49 Department of Medicine, Geriatrics Section, Boston Medical Center, Boston University School of Medicine, Boston, MA, USA
50 Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA; Department of Health Services, University of Washington, Seattle, WA, USA; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA
51 Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
52 Delft Bioinformatics Lab, Delft University of Technology, Delft, The Netherlands
53 MMDN, Univ. Montpellier, EPHE, Unité Inserm 1198, PSL Research University, Montpellier, France; CERMES3, UMR CNRS 8211—Unité Inserm 988—EHESS—Université Paris Descartes, Paris, France
54 Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA; Division of Genetic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA
55 Institute for Social Research, Survey Research Center, University of Michigan, Ann Arbor, MI, USA; School of Public Health, Epidemiology, University of Michigan, Ann Arbor, MI, USA
56 Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, and Department of Public Health, Section of Epidemiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N, Denmark; MRC Integrative Epidemiology Unit, Bristol University, Bristol, UK
57 Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA; Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA
58 Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands; Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
59 Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands; Department of Epidemiology and Biostatistics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
60 Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands; Department of Clinical Genetics, Amsterdam UMC, Amsterdam, The Netherlands
61 Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands; Nuffield Department of Population Health, University of Oxford, Oxford, UK
62 Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
63 Max Planck Institute for Demographic Research, Rostock, Germany
64 Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA
65 Center for Healthy Aging and Development Studies, National School of Development and Raissun Institute for Advanced Studies, Peking University, Beijing, China; Center for the Study of Aging and Human Development and Geriatrics Division, Medical School of Duke University, Durham, NC, USA
66 Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA; Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA; Broad Institute of MIT & Harvard, Cambridge, MA, USA
67 NHLBI’s and Boston University’s Framingham Heart Study, Framingham, MA, USA; Section of General Internal Medicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA
Pages
1-14
Publication year
2019
Publication date
Aug 2019
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2273185243
Copyright
© 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.