Abstract

Over 3000 candidate gene association studies have been performed to elucidate the genetic underpinnings of schizophrenia. However, a comprehensive evaluation of these studies’ findings has not been undertaken since the decommissioning of the schizophrenia gene (SzGene) database in 2011. As such, we systematically identified and carried out random-effects meta-analyses for all polymorphisms with four or more independent studies in schizophrenia along with a series of expanded meta-analyses incorporating published and unpublished genome-wide association (GWA) study data. Based on 550 meta-analyses, 11 SNPs in eight linkage disequilibrium (LD) independent loci showed Bonferroni-significant associations with schizophrenia. Expanded meta-analyses identified an additional 10 SNPs, for a total of 21 Bonferroni-significant SNPs in 14 LD-independent loci. Three of these loci (MTHFR, DAOA, ARVCF) had never been implicated by a schizophrenia GWA study. In sum, the present study has provided a comprehensive summary of the current schizophrenia genetics knowledgebase and has made available all the collected data as a resource for the research community.

Details

Title
The schizophrenia genetics knowledgebase: a comprehensive update of findings from candidate gene studies
Author
Liu, Chenxing 1 ; Kanazawa, Tetsufumi 2 ; Tian, Ye 3 ; Suriati Mohamed Saini 4   VIAFID ORCID Logo  ; Mancuso, Serafino 3 ; Md Shaki Mostaid 5   VIAFID ORCID Logo  ; Takahashi, Atsushi 6 ; Zhang, Dai 7 ; Zhang, Fuquan 8 ; Yu, Hao 9 ; Shin, Hyoung Doo 10 ; Cheong, Hyun Sub 11 ; Ikeda, Masashi 12 ; Kubo, Michiaki 13 ; Iwata, Nakao 12 ; Sung-Il Woo 14 ; Yue, Weihua 15   VIAFID ORCID Logo  ; Kamatani, Yoichiro 16   VIAFID ORCID Logo  ; Shi, Yongyong 17   VIAFID ORCID Logo  ; Li, Zhiqiang 17   VIAFID ORCID Logo  ; Everall, Ian 18 ; Pantelis, Christos 19   VIAFID ORCID Logo  ; Bousman, Chad 20 

1  Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Melbourne, VIC, Australia; Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA 
2  Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Melbourne, VIC, Australia; Department of Neuropsychiatry, Osaka Medical College, Osaka, Japan; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, Australia 
3  Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Melbourne, VIC, Australia 
4  Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Melbourne, VIC, Australia; Department of Psychiatry, National University of Malaysia, Kuala Lumpur, Malaysia 
5  Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Melbourne, VIC, Australia; Department of Pharmacy, Brac University, Dhaka, Bangladesh 
6  Laboratory for Statistical Analysis, RIKEN Center for Integrative, Medical Sciences, Yokohama, Japan; Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan 
7  Institute of Mental Health, Peking University Sixth Hospital, Beijing, China; Key Laboratory of Mental Health, Ministry of Health and National Clinical Research Center for Mental Disorders (Peking University), Beijing, China; Peking-Tsinghua Joint Center for Life Sciences/PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China 
8  Department of Psychiatry, The Affiliated Wuxi Mental Health Center of Nanjing Medical University, Wuxi, China 
9  Institute of Mental Health, Peking University Sixth Hospital, Beijing, China; Key Laboratory of Mental Health, Ministry of Health and National Clinical Research Center for Mental Disorders (Peking University), Beijing, China; Department of Psychiatry, Jining Medical University, Jining, China 
10  Department of Genetic Epidemiology, SNP Genetics, Inc., Seoul, Korea; Department of Life Science, Sogang University, Seoul, Korea 
11  Department of Genetic Epidemiology, SNP Genetics, Inc., Seoul, Korea 
12  Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan 
13  RIKEN Center for Integrative Medical Sciences, Yokohama, Japan 
14  Soon Chun Hyang University Hospital, Seoul, Korea 
15  Institute of Mental Health, Peking University Sixth Hospital, Beijing, China; Key Laboratory of Mental Health, Ministry of Health and National Clinical Research Center for Mental Disorders (Peking University), Beijing, China 
16  RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan 
17  Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China 
18  Institute of Psychiatry, Psychology, and Neuroscience, King’s College London, London, UK; South London and Maudsley NHS Foundation Trust, London, UK 
19  Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Melbourne, VIC, Australia; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, Australia; Department of Electrical and Electronic Engineering, Centre for Neural Engineering (CfNE), University of Melbourne, Carlton South, VIC, Australia; NorthWestern Mental Health, Melbourne, VIC, Australia 
20  Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Melbourne, VIC, Australia; Departments of Medical Genetics, Psychiatry, and Physiology & Pharmacology, University of Calgary, Calgary, AB, Canada 
Pages
1-7
Publication year
2019
Publication date
Aug 2019
Publisher
Nature Publishing Group
e-ISSN
21583188
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41398-019-0532-4
ProQuest document ID
2281087820
Copyright
© 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.