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Abstract
Lung cancer diagnosis via imaging may be confounded by the presence of indolent infectious nodules in imaging studies. This issue is pervasive in the southwestern US where coccidioidomycosis (Valley Fever) is endemic. AcidoCEST MRI is a noninvasive imaging method that quantifies the extracellular pH (pHe) of tissues in vivo, allowing tumor acidosis to be used as a diagnostic biomarker. Using murine models of lung adenocarcinoma and coccidoidomycosis, we found that average lesion pHe differed significantly between tumors and granulomas. Our study shows that acidoCEST MRI is a promising tool for improving the specificity of lung cancer diagnosis.
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Details
1 Cancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, AZ, USA
2 Bioengineering Graduate Interdisciplinary Program, University of Arizona, Tucson, AZ, USA
3 Department of Medical Imaging, University of Arizona, Tucson, AZ, USA
4 Valley Fever Center for Excellence, University of Arizona, Tucson, AZ, USA
5 Department of Cancer Systems Imaging, MD Anderson Cancer Center, Houston, TX, USA