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Abstract
The authors describe a feeder-free method of generating induced pluripotent stem cells by relying on the use of a chemically defined medium that overcomes the need for embryoid body formation and neuronal rosette isolation for neuronal precursors and terminally differentiated neuron production. This specific and efficient single-step strategy allows the production of mature neurons in 20–40 days with multiple applications, especially for modeling human pathologies.
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Details
1 Medical Genetics and Functional Genomics, Aix-Marseille University, INSERM, Marseille, France
2 Brain Dynamics Institute, Aix-Marseille University, INSERM, Marseille, France
3 Medical Genetics and Functional Genomics, Aix-Marseille University, INSERM, Marseille, France; University of California San Francisco, San Francisco, California, USA