Full text

Turn on search term navigation

© 2015. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Type 1 diabetes (T1D) is an autoimmune disease that is characterized by the specific destruction of insulin‐producing pancreatic β cells. Invariant natural killer T (iNKT) cells have been associated with development of T1D. Class I MHC‐restricted T cell‐associated molecule (CRTAM) is expressed on activated iNKT, CD8+, and CD4+ T cells, and it is associated with the pro‐inflammatory profiles of these cells. Crtam gene expression in CD3+ lymphocytes from non‐obese diabetic (NOD) mice is associated with T1D onset. However, expression of CRTAM on T cells from patients with T1D has not yet been evaluated. We compared iNKT cell (CD3+Vα24+Vβ11+) numbers and CRTAM expression in a Mexican population with recent‐onset T1D and their first‐degree relatives with control families. Remarkably, we found lower iNKT cell numbers in T1D families, and we identified two iNKT cell populations in some of the families. One iNKT cell population expressed high iTCR levels (iNKThi), whereas another expressed low levels (iNKTlo) and also expressed CRTAM. These findings support a probable genetic determinant of iNKT cell numbers and a possible role for these cells in T1D development. This study also suggests that CRTAM identifies recently activated iNKT lymphocytes.

Details

Title
Reduced iNKT cells numbers in type 1 diabetes patients and their first‐degree relatives
Author
Nonantzin Beristain‐Covarrubias 1 ; Elsy Canche‐Pool 2 ; Rita Gomez‐Diaz 3 ; Luvia E. Sanchez‐Torres 4 ; Vianney Ortiz‐Navarrete 1 

 Department of Molecular Biomedicine, Center for Research and Advanced Studies (CINVESTAV), Mexico City, Mexico 
 Immunology Laboratory, Center for Regional Investigations “Dr. Hideyo Noguchi”, Mérida, Mexico; Department of Immunology, National School of Biological Science, National Polytechnic Institute, Mexico City, Mexico 
 Research Unit on Clinical Epidemiology (UMAE), Specialty Hospital, National Medical Center, Mexican Social Security Institute, Mexico City, Mexico 
 Department of Immunology, National School of Biological Science, National Polytechnic Institute, Mexico City, Mexico 
Pages
411-419
Section
Original Research
Publication year
2015
Publication date
Dec 2015
Publisher
John Wiley & Sons, Inc.
e-ISSN
20504527
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2289716587
Copyright
© 2015. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.