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Abstract
Glioblastoma (GBM) is a primary brain cancer with an extremely poor prognosis. Recent studies in Drosophila and mammalian models (e.g., xenografts of human cancer cells into small animals) are summarized to elucidate the intercellular interactions between apoptosis-prone cancer cells and hyperproliferative cancer cells. These evolving investigations will yield insights on molecular signaling interactions in the context of post-therapeutic phenotypic changes in human cancers.
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Details
1 Center for Tissue Regeneration and Engineering at Dayton (TREND), Department of Biology, University of Dayton, Dayton, Ohio, USA
2 PreMedical Programs, University of Dayton, Dayton, Ohio, USA
3 Department of Neurological Surgery The Ohio State University, Columbus, Ohio, USA
4 Center for Tissue Regeneration and Engineering at Dayton (TREND), Department of Biology, University of Dayton, Dayton, Ohio, USA; PreMedical Programs, University of Dayton, Dayton, Ohio, USA
5 Department of Neurological Surgery The Ohio State University, Columbus, Ohio, USA; James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA