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© 2014. This work is published under http://creativecommons.org/licenses/by-nc-nd/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Increased regulatory demands for pediatric drug development research have fostered interest in the use of modeling and simulation among industry and academia. Physiologically based pharmacokinetic (PBPK) modeling offers a unique modality to incorporate multiple levels of information to estimate age‐specific pharmacokinetics. This tutorial will serve to provide the reader with a basic understanding of the procedural steps to developing a pediatric PBPK model and facilitate a discussion of the advantages and limitations of this modeling technique.

CPT Pharmacometrics Syst. Pharmacol. (2014) 3, e148; doi:10.1038/psp.2014.45; published online 19 November 2014

Details

Title
Physiologically Based Pharmacokinetic Modeling and Simulation in Pediatric Drug Development
Author
Maharaj, A R 1 ; Edginton, A N 1 

 School of Pharmacy, University of Waterloo, Waterloo, Ontario, Canada 
Pages
1-13
Section
Tutorial
Publication year
2014
Publication date
Nov 2014
Publisher
John Wiley & Sons, Inc.
e-ISSN
21638306
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2290117433
Copyright
© 2014. This work is published under http://creativecommons.org/licenses/by-nc-nd/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.