Abstract
Homing of intraarterially infused rat mesenchymal stem cells (rMSCs) in the brain of rats bearing a 6-hydroxydopamine (6-OHDA)-induced lesion of the nigrostriatal tract was evaluated to establish whether the toxin-induced damage enables MSC passage across the blood-brain barrier (BBB) or if transient BBB disruption is necessary. Appreciable delivery of rMSCs to the brain of lesioned animals occurred only after mannitol pretreatment. rMSC infusion induced progressive normalization of the pathological response to apomorphine administration.
You have requested "on-the-fly" machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Show full disclaimer
Neither ProQuest nor its licensors make any representations or warranties with respect to the translations. The translations are automatically generated "AS IS" and "AS AVAILABLE" and are not retained in our systems. PROQUEST AND ITS LICENSORS SPECIFICALLY DISCLAIM ANY AND ALL EXPRESS OR IMPLIED WARRANTIES, INCLUDING WITHOUT LIMITATION, ANY WARRANTIES FOR AVAILABILITY, ACCURACY, TIMELINESS, COMPLETENESS, NON-INFRINGMENT, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Your use of the translations is subject to all use restrictions contained in your Electronic Products License Agreement and by using the translation functionality you agree to forgo any and all claims against ProQuest or its licensors for your use of the translation functionality and any output derived there from. Hide full disclaimer
Details
1 Laboratory of Functional Neurochemistry, Center for Research in Neurodegenerative Diseases
2 Laboratory of Neurophysiology of Integrative Autonomic Systems, “C. Mondino” National Neurological Institute, Pavia, Italy
3 Immunology and Transplantation Laboratory/Cell Factory/Pediatric Hematology/Oncology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy