Abstract

The cartilage regeneration potential of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) with a hyaluronic acid (HA) hydrogel composite has shown remarkable results in small animal models. A minipig model was used to confirm the consistent regenerative potential. This evidence of consistent cartilage regeneration using composites of hUCB-MSCs and HA hydrogel in a large animal model could be a stepping stone to a human clinical trial in the future.

Details

Title
Cartilage Repair Using Composites of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells and Hyaluronic Acid Hydrogel in a Minipig Model
Author
Chul-Won, Ha 1 ; Park Yong-Beom 1 ; Jun-Young, Chung 2 ; Park Yong-Geun 3 

1  Department of Orthopedic Surgery, Stem Cell and Regenerative Medicine Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea 
2  Department of Orthopedic Surgery, Ajou University Hospital, Ajou University School of Medicine, Seoul, Republic of Korea 
3  Department of Orthopedic Surgery, Jeju National University Hospital, Jeju National University School of Medicine, Jeju-do, Republic of Korea 
Pages
1044-1051
Section
Tissue Engineering and Regenerative Medicine
Publication year
2015
Publication date
Sep 2015
Publisher
Oxford University Press
ISSN
21576564
e-ISSN
21576580
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.5966/sctm.2014-0264
ProQuest document ID
2290214057
Copyright
© 2015. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.