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© 2013. This work is published under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

The primary Afrotropical malaria mosquito vector Anopheles gambiae sensu stricto has a complex population structure. In west Africa, this species is split into two molecular forms and displays local and regional variation in chromosomal arrangements and behaviors. To investigate patterns of macrogeographic population substructure, 25 An. gambiae samples from 12 African countries were genotyped at 13 microsatellite loci. This analysis detected the presence of additional population structuring, with the M-form being subdivided into distinct west, central, and southern African genetic clusters. These clusters are coincident with the central African rainforest belt and northern and southern savannah biomes, which suggests restrictions to gene flow associated with the transition between these biomes. By contrast, geographically patterned population substructure appears much weaker within the S-form.

Details

Title
Geographic population structure of the African malaria vector Anopheles gambiae suggests a role for the forest-savannah biome transition as a barrier to gene flow
Author
Pinto, J 1 ; Egyir-Yawson, A 2 ; Vicente, J L 1 ; Gomes, B 1 ; Santolamazza, F 3 ; Moreno, M 4 ; Charlwood, J D 5 ; Simard, F 6 ; Elissa, N 7 ; Weetman, D 8 ; Donnelly MJ 8 ; Caccone, A 9 ; Della Torre A 3 

 Unidade de Parasitologia Médica, Centro de Malária e outras Doenças Tropicais, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisbon, Portugal 
 Unidade de Parasitologia Médica, Centro de Malária e outras Doenças Tropicais, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisbon, Portugal; Biotechnology and Nuclear Agriculture Research Institute, Ghana Atomic Energy Commission, Legon, Ghana 
 Dipartimento di Sanità Pubblica e Malattie Infettive, Istituto Pasteur-Fondazione Cenci-Bolognetti, Università di Roma “La Sapienza”, Rome, Italy 
 Division of Infectious Diseases, School of Medicine, University of California San Diego, La Jolla, CA, USA 
 Unidade de Parasitologia Médica, Centro de Malária e outras Doenças Tropicais, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisbon, Portugal; Vector Group, Liverpool School of Tropical Medicine, Liverpool, UK 
 MIVEGEC (Maladies Infectieuses et Vecteurs: Ecologie, Genetique, Evolution et Contrôle), UMR IRD224-CNRS5290-UM1-UM2, Institut de Recherche pour le Développement, Montpellier, France 
 Unité d'Entomologie Médicale, Institut Pasteur de Madagascar, Antananarivo, Madagascar 
 Vector Group, Liverpool School of Tropical Medicine, Liverpool, UK 
 Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT, USA 
Pages
910-924
Section
Original Articles
Publication year
2013
Publication date
Sep 2013
Publisher
John Wiley & Sons, Inc.
e-ISSN
17524571
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2290721111
Copyright
© 2013. This work is published under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.