Abstract

Aurantiadioic acids A (1) and B (2), two new furan-containing polyketides, and aurantoic acid A (3), a new natural product, were isolated from the liquid fermentation of the sika deer dung-derived actinomycete Actinocorallia aurantiaca. The structures of the new compounds were established by extensive spectroscopic methods, including 1D & 2D NMR, HRESIMS spectroscopic analysis. The absolute configuration of 3 was assigned by comparison of the specific optical rotations with the reported derivatives. Biological activity evaluations suggested that compounds 1–3 showed weak inhibition on NO production in the murine monocytic RAW 264.7 macrophages with IC50 values of 35.8, 41.8, 45.2 μM, respectively. Compound 3 showed weak inhibition on influenza A virus (A/PuertoRico/8/1934, H1N1) with an EC50 value of 35.9 μM, and a selective index higher than 13.3.

Details

Title
Three New Compounds from the Actinomycete Actinocorallia aurantiaca
Author
Kai-Yue, Han 1 ; Wu, Xing 1 ; Jiang, Chenglin 2 ; Huang, Rong 1 ; Zheng-Hui, Li 1 ; Feng, Tao 1 ; He-Ping, Chen 1   VIAFID ORCID Logo  ; Ji-Kai, Liu 1 

1  School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, People’s Republic of China 
2  State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Institute of Microbiology, School of Life Sciences, Yunnan University, Kunming, People’s Republic of China 
Pages
351-354
Publication year
2019
Publication date
Oct 2019
Publisher
Springer Nature B.V.
ISSN
21922195
e-ISSN
21922209
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1007/s13659-019-00217-0
ProQuest document ID
2291111375
Copyright
Natural Products and Bioprospecting is a copyright of Springer, (2019). All Rights Reserved., © 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.