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© 2015. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

LTP-like plasticity measured by visual evoked potentials (VEP) can be induced in the intact human brain by presenting checkerboard reversals. Also associated with LTP-like plasticity, around two third of participants respond to transcranial magnetic stimulation with a paired-associate stimulation (PAS) protocol with a potentiation of their motor evoked potentials. LTP-like processes are also required for verbal and motor learning tasks. We compared effect sizes, responder rates and intercorrelations as well as the potential influence of attention between these four assessments in a group of 37 young and healthy volunteers. We observed a potentiation effect of the N75 and P100 VEP component which positively correlated with plasticity induced by PAS. Subjects with a better subjective alertness were more likely to show PAS and VEP potentiation. No correlation was found between the other assessments. Effect sizes and responder rates of VEP potentiation were higher compared to PAS. Our results indicate a high variability of LTP-like effects and no evidence for a system-specific nature. As a consequence, studies wishing to assess individual levels of LTP-like plasticity should employ a combination of multiple assessments.

Details

Title
LTP-like plasticity in the visual system and in the motor system appear related in young and healthy subjects
Author
Klöppel, Stefan; Lauer, Eliza; Peter, Jessica; Minkova, Lora; Nissen, Christoph; Normann, Claus MD; Reis, Janine; Mainberger, Florian; Bach, Michael PhD; Lahr, Jacob
Section
Original Research ARTICLE
Publication year
2015
Publication date
Sep 24, 2015
Publisher
Frontiers Research Foundation
e-ISSN
16625161
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2291434709
Copyright
© 2015. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.